ArticleEnvironmental science and pollution research international2020
Silver nanoparticles-induced nephrotoxicity in rats: the protective role of red beetroot (Beta vulgaris) juice.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 23 citations in OpenAlex.
- Ameliorative Effect of Beetroot Against Folic Acid Deficiency: A Review.Food science & nutrition · 2026Review
- Environmental Nephrotoxicity Across the Life Course: Oxidative Stress Mechanisms and Opportunities for Early Intervention.Antioxidants (Basel, Switzerland) · 2025Review
- Nephroprotective and Anti-Diabetic Potential ofMedicina (Kaunas, Lithuania) · 2024Article
- Beet leaf (beta vulgaris L.) extract attenuates iron-induced testicular toxicity: Experimental and computational approach.Heliyon · 2023Article
- The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix.Polymers · 2022Article
- Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats.Scientific reports · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
The present study was designed to investigate the nephrotoxicity of silver nanoparticles (AgNPs; 80 mg/kg; > 100 nm) and to evaluate the protective effect exercised by Beta vulgaris (beetroot) juice (RBR; 200 mg/kg) on male rats' kidney. Serum-specific parameters (urea, creatinine, electrolytes and histopathology of kidney tissue) were examined to assess the AgNPs nephrotoxicity effect. Moreover, this study analysed oxidative stress (lipid peroxidation, glutathione, superoxide dismutase and catalase) and anti-apoptotic markers (Bcl-2). AgNPs intoxication increased kidney function marker levels and lipid peroxidation and decreased the glutathione, superoxide dismutase and catalase activities in kidney tissue. Additionally, Bcl-2 expression was downregulated following AgNPs intoxication. Moreover, AgNPs induced a significant increase in renal DNA damage displayed as an elevation in tail length, tail DNA percentage and tail moment. Interestingly, RBR post-treatment restored the biochemical and histological alterations induced by AgNPs exposure, reflecting its nephroprotective effect. Collectively, the present data suggest that RBR could be used as a potential therapeutic intervention to prevent AgNPs-induced nephrotoxicity.
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