SynthesisEndocrine2020
Prevalence of and risk factors for hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis.
Synthesis in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Pooled it
- Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid: A Systematic Review and Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2022Pooled it
- Thyroid hormone therapy initiation after hemithyroidectomy: treatment burden, timing, and predictors in a population-based cohort.Endocrine · 2026Article
- Hemithyroidectomy versus total thyroidectomy for patients with differentiated thyroid cancer: a systematic review and meta-analysis.Gland surgery · 2025Article
- Ultrasound-guided needle localization in trans-mammary endoscopic thyroidectomy: a case report.Journal of medical case reports · 2025Article
- A Clinical Risk Score for Thyroid Hormone Therapy After Partial Thyroidectomy.The Journal of surgical research · 2025Article
- Incidence and risk factors for early thyroxin supplementation therapy after hemithyroidectomy for benign conditions in Europe. A Eurocrine® registry-based study.Updates in surgery · 2025Article
- Role of Preoperative Thyroid-Stimulating Hormone Levels in the Prediction of Thyroid Hormone Replacement after Hemithyroidectomy.International archives of otorhinolaryngology · 2025Article
- Hypothyroidism After Hemithyroidectomy: A Retrospective Analysis of Temporal Trends and Key Risk Factors.Journal of clinical medicine · 2025Article
- Hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis.Thyroid research · 2024Review
- MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer.European journal of nuclear medicine and molecular imaging · 2024Article
- Differentiated thyroid cancer: a focus on post-operative thyroid hormone replacement and thyrotropin suppression therapy.Endocrine · 2024Review
- Dynamic risk assessment in patients with differentiated thyroid cancer.Reviews in endocrine & metabolic disorders · 2024Review
- Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography.European journal of nuclear medicine and molecular imaging · 2023Article
- Operative Management of Thyroid Disease in Older Adults.Journal of the Endocrine Society · 2023Review
- Risk of Adverse Pregnancy Outcomes in Young Women with Thyroid Cancer: A Systematic Review and Meta-Analysis.Cancers · 2022Review
- Predictive factors for hypothyroidy after hemithyroidectomy.F1000Research · 2022Article
- Clinical Course of Early Postoperative Hypothyroidism Following Thyroid Lobectomy in Pediatrics.Thyroid : official journal of the American Thyroid Association · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis systematic review and meta-analysis evaluated the prevalence of and risk factors for hypothyroidism following hemithyroidectomy as new evidence obtained in recent years warranted an update of previous meta-analyses.
methodsThe PubMed, Embase, and Cochrane Library databases were searched through November 1, 2019, for articles examining the hypothyroidism prevalence and risk factors after lobectomy. The prevalence rate, risk ratio (RR), weighted mean difference (WMD) and standardized mean difference (SMD) were assessed by conducting a meta-analysis of proportions, binary variables, and continuous variables, respectively, using random-effects models.
resultsFifty-one studies showed a pooled risk of 29.9% (95% confidence interval (CI), 24.6-35.2%) for hypothyroidism following hemithyroidectomy. Risk factors for the development of postoperative hypothyroidism included the female sex (RR, 1.169; 95% CI, 1.040-1.314; P = 0.009), a higher preoperative thyrotropin (TSH) level (RR, 2.955; 95% CI, 2.399-3.640; P = 0.000), a lower preoperative FT4 level (SMD, -0.818; 95% CI, -1.623--0.013; P = 0.047), concomitant lymphocyte infiltration (RR, 1.558; 95% CI, 1.203-2.018; P = 0.001), Hashimoto's thyroiditis (HT) (RR, 1.480; 95% CI, 1.192-1.838; P = 0.000), a lighter weight of the remaining gland (WMD, -2.740; 95% CI, -3.708--1.772; P = 0.000), and a right side lobectomy (RR, 1.404; 95% CI, 1.075-1.835; P = 0.013).
conclusionsHypothyroidism is a significant complication after lobectomy, and appropriate and personalized surgical strategies should be designed after a careful preoperative assessment based on the estimated risk of hypothyroidism and risk factors.
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Registered trials
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