Evidence map›Paper›PMID 32637948›Full record

ArticlebioRxiv : the preprint server for biology2020

Genetic architecture of host proteins interacting with SARS-CoV-2.

Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Johannes Raffler, Nicola D Kerrison, Erin Oerton, Victoria P W Auyeung, Jian'an Luan, Chris Finan, Juan P Casas and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 15 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Maik PietznerMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Eleanor WheelerMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Julia Carrasco-ZaniniMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Johannes RafflerInstitute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Nicola D KerrisonMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Erin OertonMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Victoria P W AuyeungMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Chris FinanInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT, UK.
Juan P CasasDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Rachel OstroffSomaLogic, Inc., Boulder, CO, USA.
Steve A WilliamsSomaLogic, Inc., Boulder, CO, USA.
Gabi KastenmüllerInstitute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Markus RalserThe Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Eric R GamazonMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Aroon D HingoraniInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT, UK.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
University of Cambridge · GBHelmholtz Zentrum München · DESomaLogic (United States) · USBrigham and Women's Hospital · USHealth Data Research UK · GBThe Francis Crick Institute · GBUniversity College London · GB

Funding

Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-ADU01AG061359 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2018 to 2022
$10.0M
Metabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to TreatmentRF1AG059093 · NIA · DUKE UNIVERSITY · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2018
$5.9M
Metabolic Network Analysis of Biochemical Trajectories in Alzheimer's DiseaseRF1AG057452 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2017 to 2017
$3.5M
Gut Liver Brain Biochemical Axis in Alzheimer's DiseaseRF1AG058942 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, VAN DUIJN, CORNELIA MARJA · 2018 to 2018
$3.4M
Functional Genomics: A Phenome-wide SurveyR35HG010718 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAMAZON, ERIC R · 2019 to 2023
$2.2M
Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_12015/1NHGRI NIH HHS R35 HG010718NIA NIH HHS RF1 AG057452NIA NIH HHS RF1 AG058942NIA NIH HHS RF1 AG059093NIA NIH HHS U01 AG061359NIA NIH HHS U19 AG063744Wellcome Trust FC001134
6 · The paper itself

Abstract

Strategies to develop therapeutics for SARS-CoV-2 infection may be informed by experimental identification of viral-host protein interactions in cellular assays and measurement of host response proteins in COVID-19 patients. Identification of genetic variants that influence the level or activity of these proteins in the host could enable rapid 'in silico' assessment in human genetic studies of their causal relevance as molecular targets for new or repurposed drugs to treat COVID-19. We integrated large-scale genomic and aptamer-based plasma proteomic data from 10,708 individuals to characterize the genetic architecture of 179 host proteins reported to interact with SARS-CoV-2 proteins or to participate in the host response to COVID-19. We identified 220 host DNA sequence variants acting in

Identifiers

PMID32637948
PMCPMC7337378
OpenAlexW3038832438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.