Evidence map›Paper›PMID 32637938›Full record

ReviewNeuroscience insights2020

The Effects of Early-Life Iron Deficiency on Brain Energy Metabolism.

Thomas W Bastian, Raghavendra Rao, Phu V Tran, Michael K Georgieff

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience insights, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Thomas W BastianDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0001-5486-9471
Raghavendra RaoDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USA.
Phu V TranDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USA.
Michael K GeorgieffDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota Medical Center · US

Funding

Newborn Iron DeficiencyR01HD094809 · NICHD · UNIVERSITY OF MINNESOTA · PI Michael K. Georgieff · 2018 to 2026
$3.6M
Roles of Iron-Dependent PHD and JARID in Early-Life Iron Deficiency-Induced Adult Neural Gene DysregulationR01NS099178 · NINDS · UNIVERSITY OF MINNESOTA · PI TRAN, PHU V. · 2017 to 2021
$1.6M
NICHD NIH HHS R01 HD094809NINDS NIH HHS R01 NS099178
6 · The paper itself

Abstract

Iron deficiency (ID) is one of the most prevalent nutritional deficiencies in the world. Iron deficiency in the late fetal and newborn period causes abnormal cognitive performance and emotional regulation, which can persist into adulthood despite iron repletion. Potential mechanisms contributing to these impairments include deficits in brain energy metabolism, neurotransmission, and myelination. Here, we comprehensively review the existing data that demonstrate diminished brain energetic capacity as a mechanistic driver of impaired neurobehavioral development due to early-life (fetal-neonatal) ID. We further discuss a novel hypothesis that permanent metabolic reprogramming, which occurs during the period of ID, leads to chronically impaired neuronal energetics and mitochondrial capacity in adulthood, thus limiting adult neuroplasticity and neurobehavioral function. We conclude that early-life ID impairs energy metabolism in a brain region- and age-dependent manner, with particularly strong evidence for hippocampal neurons. Additional studies, focusing on other brain regions and cell types, are needed.

Indexed as

brain developmentenergy metabolismhippocampusIroniron deficiencymitochondria

Identifiers

PMID32637938
PMCPMC7324901
OpenAlexW3039938431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.