Evidence map›Paper›PMID 32637831›Full record

ArticleACS omega2020

Zein Nanoparticles Impregnated with Eugenol and Garlic Essential Oils for Treating Fish Pathogens.

Angélica I S Luis, Estefânia V R Campos, Jhones L de Oliveira, Mariana Guilger-Casagrande, Renata de Lima, Rodrigo F Castanha, Vera L S S de Castro, Leonardo F Fraceto

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  4. Chitosan-Based Nanoencapsulation of Mānuka Oil for Periodontal Treatment.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Angélica I S LuisInstitute of Science and Technology, Laboratory of Environmental Nanotechnology, São Paulo State University (UNESP), Sorocaba, SP 18087-180, Brazil.
Estefânia V R CamposFederal University of ABC, Santo André, São Paulo 09210-580, Brazil.
Jhones L de OliveiraInstitute of Science and Technology, Laboratory of Environmental Nanotechnology, São Paulo State University (UNESP), Sorocaba, SP 18087-180, Brazil.
Mariana Guilger-CasagrandeLaboratory of Bioactivity Assessment and Toxicology of Nanomaterials (LABiToN), University of Sorocaba, Sorocaba, SP 18023-000, Brazil.
Renata de LimaLaboratory of Bioactivity Assessment and Toxicology of Nanomaterials (LABiToN), University of Sorocaba, Sorocaba, SP 18023-000, Brazil.
Rodrigo F CastanhaLaboratory of Ecotoxicology and Biosafety, Embrapa Environment, Jaguariúna, São Paulo 13820-000, Brazil.
Vera L S S de CastroLaboratory of Ecotoxicology and Biosafety, Embrapa Environment, Jaguariúna, São Paulo 13820-000, Brazil.
Leonardo F FracetoInstitute of Science and Technology, Laboratory of Environmental Nanotechnology, São Paulo State University (UNESP), Sorocaba, SP 18087-180, Brazil.
Universidade Estadual Paulista (Unesp) · BRBrazilian Agricultural Research Corporation · BRUniversidade de Sorocaba · BRUniversidade Federal do ABC · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The supply of food derived from aquaculture has increased significantly in recent years. The aim of this industrial sector is to produce sustainable products to meet the needs of consumers, providing food security and nutritional benefits. The development of aquaculture has faced challenges including disease outbreaks that can cause substantial economic losses. These diseases can be controlled using chemicals such as antibiotics. However, the indiscriminate use of these substances can have major negative impacts on human health and the environment with the additional risk of the emergence of resistant organisms. The present manuscript describes the use of phytotherapy in association with nanotechnology in order to obtain a more effective and less harmful system for the control of bacterial diseases in fish. Zein nanoparticles associated with eugenol and garlic essential oil were prepared through antisolvent precipitation and characterized. Zein nanoparticles are promising carrier systems as zein proteins are biodegradable and biocompatible and, in this way, good candidates for encapsulation of active ingredients. The system presented good physicochemical properties with an average particle diameter of approximately 150 nm, a polydispersity index lower than 0.2, and a zeta potential of approximately 30 mV. High encapsulation efficiency was obtained for the active compounds with values higher than 90%, and the compounds were protected against degradation during storage (90 days). The nanoparticle formulations containing the botanical compounds also showed less toxicity in the tests performed with a biomarker (

Identifiers

PMID32637831
PMCPMC7331071
OpenAlexW3036225762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.