Evidence map›Paper›PMID 32637748›Full record

ArticleBioactive materials2020

Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering.

Huanhuan Liu, Mingli Lin, Xue Liu, Ye Zhang, Yuyu Luo, Yanyun Pang, Haitao Chen, Dongwang Zhu, Xue Zhong, Shiqing Ma and 3 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Engineering Efferocytosis for Bone Regeneration.Macromolecular bioscience · 2025
    Review
  3. Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  16. Article
  17. Article
  18. Review
  19. Biomineralization of Collagen-Based Materials for Hard Tissue Repair.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Huanhuan LiuSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Mingli LinDepartment of Stomatology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, 361004, China.
Xue LiuSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Ye ZhangSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Yuyu LuoThe Third Central Clinical College of Tianjin Medical University, Tianjin, 300170, China.
Yanyun PangSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Haitao ChenSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Dongwang ZhuSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Xue ZhongSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Shiqing MaSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Yanhong ZhaoSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Qiang YangDepartment of Spine Surgery, Tianjin Hospital, Tianjin, 300211, China.
Xu ZhangSchool of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Stomatology Hospital · CNTianjin Hospital · CNTianjin Medical University · CNZhongshan Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pure collagen is biocompatible but lacks inherent osteoinductive, osteoimmunomodulatory and antibacterial activities. To obtain collagen with these characteristics, we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization (SSM) of collagen. In the SSM model, amorphous mineral nanoparticles (AMN) (amorphous SrCO

Indexed as

Bioactive elementsBone tissue engineeringCollagen scaffoldSynchronous self-assembly/mineralization

Identifiers

PMID32637748
PMCPMC7327760
OpenAlexW3037119855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.