Evidence map›Paper›PMID 32637718›Full record

ArticleJournal of clinical and translational research2020

Cardiovascular, endothelial function, and immune markers in response to treatment with a polysaccharide in HIV

John E Lewis, Steven E Atlas, Muhammad H Abbas, Ammar Rasul, Ashar Farooqi, Laura A Lantigua, Frederick Michaud, Sharon Goldberg, Lucas C Lages, Jinrun Gao and 9 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of clinical and translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

John E LewisDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Steven E AtlasDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Muhammad H AbbasDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Ammar RasulDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Ashar FarooqiDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Laura A LantiguaDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Frederick MichaudDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Sharon GoldbergDepartment of Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Lucas C LagesDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Jinrun GaoBarclay's, Inc., Wilmington, DE, USA.
Oscar L HigueraDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Andrea FialloDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Philip D HarveyDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Eduard TiozzoDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Judi M WoolgerDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Stephanie CiraulaDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Armando MendezDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Allan RodriguezDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Janet KonefalBarclay's, Inc., Wilmington, DE, USA.
University of Miami · USUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimGiven the ongoing problems of hypertension and endothelial dysfunction in the HIV population, the primary objective of the study was to assess the cardiovascular, endothelial function, and immune markers in response to rice bran arabinoxylan compound (RBAC) treatment in a sample of HIV STUDY

designA randomized, double-blind placebo-controlled trial of 6 months was used to execute the study. MATERIALS AND

methodsForty-seven subjects were enrolled and randomly assigned to one of two study conditions (

resultsThe effect of treatment (RBAC versus placebo) was significant (Wilks' λ=0.92, F[3, 102]=3.07,

conclusionsThe overall significant interaction suggests varying responses in the dependent variables between RBAC and placebo over time, which is being driven by systolic blood pressure, as it decreased in the RBAC group, but increased in the placebo group. In addition, CD4 RELEVANCE FOR PATIENTS: Persons with HIV on ART suffer disproportionately from hypertension and endothelial dysfunction compared to the non-infected population, and conventional medical therapy does not alleviate these issues. RBAC is a safe, low-risk alternative that may help to improve the overall quality of life of these patients through modest improvements in these biomarkers plus CD4

Indexed as

CD4+endothelial functionHIVhypertensionnutritional supplementpolysacchariderice bran arabinoxylan compoundsystolic blood pressure

Identifiers

PMID32637718
PMCPMC7333168
OpenAlexW3041628293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.