ArticleSynthetic and systems biotechnology2020
Discovery and modification of cytochrome P450 for plant natural products biosynthesis.
Article in Synthetic and systems biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 82 citations in OpenAlex.
- Chromosome-scale genome assembly of Artabotrys hexapetalus provides insights into its evolution and terpenoid biosynthesis.BMC plant biology · 2026Article
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- Protein design drives synthetic biology research of plant natural products.Biodesign research · 2025Review
- CYP82G1 Enzyme Functions as Chromone Hydroxylase in the Biosynthesis of 6-Hydroxy-2-(2-Phenylethyl)chromone in Aquilaria sinensis.Plant biotechnology journal · 2025Article
- Metabolic engineering inaBIOTECH · 2025Review
- Soybean genome‑wide association study of seed weight, protein, and oil content in the southeastern USA.Molecular genetics and genomics : MGG · 2025Article
- Thylakoid Targeting Improves Stability of a Cytochrome P450 in the CyanobacteriumACS synthetic biology · 2025Article
- Mechanistic Perspective on C-N and C-S Bond Construction Catalyzed by Cytochrome P450 Enzymes.ACS bio & med chem Au · 2025Review
- Whole-Genome Sequence Analysis ofJournal of fungi (Basel, Switzerland) · 2024Article
- P450Rdb: A manually curated database of reactions catalyzed by cytochrome P450 enzymes.Journal of advanced research · 2024Article
- Identification and Expression Analysis of Cytochrome P450 Genes Probably Involved in Triterpenoid Saponins Biosynthesis inInternational journal of molecular sciences · 2024Article
- N-terminal truncated phospholipase A1 accessory protein PlaS from Serratia marcescens alleviates inhibitory on host cell growth and enhances PlaA1 enzymatic activity.Bioresources and bioprocessing · 2024Article
- Integrative analysis of the metabolome and transcriptome provides insights into the mechanisms of lignan biosynthesis in Herpetospermum pedunculosum (Cucurbitaceae).BMC genomics · 2024Article
- Divergent proteomic profiles of opium poppy cultivars.Turkish journal of biology = Turk biyoloji dergisi · 2024Article
- Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model.Research (Washington, D.C.) · 2024Article
- Emerging functions within the enzyme families of plant alkaloid biosynthesis.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2023Article
- Differential RNA-Seq Analysis Predicts Genes Related to Terpene Tailoring inPlants (Basel, Switzerland) · 2023Article
- Developing TeroENZ and TeroMAP modules for the terpenome research platform TeroKit.Database : the journal of biological databases and curation · 2023Article
- Genome-based identification of the CYP75 gene family in Orchidaceae and its expression patterns inFrontiers in plant science · 2023Article
- Functional characterization of Cinnamate 4-hydroxylase gene family in soybean (Glycine max).PloS one · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome P450s are widespread in nature and play key roles in the diversification and functional modification of plant natural products. Over the last few years, there has been remarkable progress in plant P450s identification with the rapid development of sequencing technology, "omics" analysis and synthetic biology. However, challenges still persist in respect of crystal structure, heterologous expression and enzyme engineering. Here, we reviewed several research hotspots of P450 enzymes involved in the biosynthesis of plant natural products, including P450 databases, gene mining, heterologous expression and protein engineering.
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