Evidence map›Paper›PMID 32637666›Full record

ArticleSynthetic and systems biotechnology2020

Cell-free synthesis system-assisted pathway bottleneck diagnosis and engineering in

Rongzhen Tian, Minghu Wang, Jintian Shi, Xiaolong Qin, Haoyu Guo, Xuanjie Jia, Jianghua Li, Long Liu, Guocheng Du, Jian Chen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Natural products research in the modern age.Synthetic and systems biotechnology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rongzhen TianScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Minghu WangScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Jintian ShiScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Xiaolong QinScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Haoyu GuoScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Xuanjie JiaScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Jianghua LiScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Long LiuScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Guocheng DuScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Jian ChenKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Yanfeng LiuScience Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
Jiangnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic engineering is a key technology for cell factories construction by rewiring cellular resources to achieve efficient production of target chemicals. However, the existence of bottlenecks in synthetic pathway can seriously affect production efficiency, which is also one of the core issues for metabolic engineers to solve. Therefore, developing an approach for diagnosing potential metabolic bottlenecks in a faster and simpler manner is of great significance to accelerate cell factories construction. The cell-free reaction system based on cell lysates can transfer metabolic reactions from

Indexed as

Bacillus subtilisCell-free synthesis systemPathway bottleneck diagnosis

Identifiers

PMID32637666
PMCPMC7320236
OpenAlexW3037274379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.