Evidence map›Paper›PMID 32637663›Full record

ArticleParasite epidemiology and control2020

Clinical and laboratory findings in tick-borne encephalitis virus infection.

Nicole Barp, Alessandro Trentini, Mariachiara Di Nuzzo, Valeria Mondardini, Ermenegildo Francavilla, Carlo Contini

Open access · goldAbstract read
In one paragraph

Article in Parasite epidemiology and control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Integrating metagenomics and metatranscriptomics intoThe Journal of general virology · 2026
    Review
  4. Review
  5. Article
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  7. Article
  8. Clinical characteristics and factors affecting disease severity in hospitalized tick-borne encephalitis patients in Norway from 2018 to 2022.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Observational
  9. Article
  10. Tick-Borne Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023
    Article
  11. Tick-Borne Encephalitis (TBE): From Tick to Pathology.Journal of clinical medicine · 2023
    Review
  12. Review
  13. Article
  14. Fatal Case of Imported Tick-Borne Encephalitis in South Serbia.Tropical medicine and infectious disease · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicole BarpDept Medical Sciences, Section of Infectious Diseases, University of Ferrara, Italy.
Alessandro TrentiniDept Biomedical Sciences, Section of Biochemistry, Molecular Biology and Medical Genetics, University of Ferrara, Italy.
Mariachiara Di NuzzoDept Medical Sciences, Section of Infectious Diseases, University of Ferrara, Italy.
Valeria MondardiniInfectious Diseases, Belluno Medical Hospital "San Martino", Ulss1 Dolomiti, Italy.
Ermenegildo FrancavillaInfectious Diseases, Belluno Medical Hospital "San Martino", Ulss1 Dolomiti, Italy.
Carlo ContiniDept Medical Sciences, Section of Infectious Diseases, University of Ferrara, Italy.
University of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTick-Borne Encephalitis (TBE), a disease caused by Tick-Borne Encephalitis Virus (TBEV), is emerging in Italy. This study aimed to characterize the epidemiological, clinical, laboratory, imaging and electroencephalogram characteristics in Belluno, North-East Italy.

results76% were males, mean age 53 years; 50% did not report tick bite. 72% had a biphasic course, 42% a monophasic one, 8 cases of abortive TBE. Mostly no specific symptoms were observed, together with neurological signs and symptoms. None died, but 35% had sequelae at the one-month follow-up. Men had a higher risk of having neurological/neurocognitive sequelae; paresthesia or tremors were associated independently with sequelae. In terms of laboratory data, thrombocytopenia, neutropenia and lymphocytosis were associated with the first phase (

conclusionsAlthough patients have not reported a tick bite, TBEV infection should be considered for diagnosis. Usually no specific symptoms are reported along with neurological signs and symptoms. The biphasic course is more often described than the monophasic course; abortive TBE is sometimes present. Paresthesia and tremors are independently associated with neurological/neurocognitive sequelae; men have a higher risk of having sequelae. The first phase is probably associated with thrombocytopenia, neutropenia and lymphocytosis; the second with monocytosis, lymphocytopenia, high levels of CRP and ESR. Electrolyte disorders, high levels of transaminases, GGT, bilirubin, CPK, LDH, fibrinogen and amylase may characterize TBEV infection.

Indexed as

Abnormal laboratory dataBiphasic courseMonophasic courseNeurological/neurocognitive sequelaeTick-borne encephalitisTick-borne encephalitis virus (TBEV)

Identifiers

PMID32637663
PMCPMC7327414
OpenAlexW3036976764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.