Evidence map›Paper›PMID 32637623›Full record

ArticleScience advances2020

4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction.

Haitao Cui, Chengyu Liu, Timothy Esworthy, Yimin Huang, Zu-Xi Yu, Xuan Zhou, Hong San, Se-Jun Lee, Sung Yun Hann, Manfred Boehm and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed.

  1. Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  18. 3D Bioprinting Functional Engineered Heart Tissues.International journal of molecular sciences · 2025
    Review
  19. Article
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Haitao CuiDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-0641-6029
Chengyu LiuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5136-9225
Timothy EsworthyDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-0826-2860
Yimin HuangNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Zu-Xi YuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Xuan ZhouDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Hong SanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Se-Jun LeeDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-3906-9692
Sung Yun HannDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Manfred BoehmNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2251-3638
Muhammad MohiuddinCardiac Xenotransplantation Program, Department of Surgery, University of Maryland, Baltimore, MD 21201, USA.
John P FisherFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0002-4019-348X
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0003-3009-045X

Funding

Transgenic CoreZICHL005907 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LIU, CHENGYU · 2010 to 2025
$25.8M
Pathology CoreZICHL005904 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YU, ZU XI · 2010 to 2023
$11.6M
A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

There has been considerable progress in engineering cardiac scaffolds for the treatment of myocardial infarction (MI). However, it is still challenging to replicate the structural specificity and variability of cardiac tissues using traditional bioengineering approaches. In this study, a four-dimensional (4D) cardiac patch with physiological adaptability has been printed by beam-scanning stereolithography. By combining a unique 4D self-morphing capacity with expandable microstructure, the specific design has been shown to improve both the biomechanical properties of the patches themselves and the dynamic integration of the patch with the beating heart. Our results demonstrate improved vascularization and cardiomyocyte maturation in vitro under physiologically relevant mechanical stimulation, as well as increased cell engraftment and vascular supply in a murine chronic MI model. This work not only potentially provides an effective treatment method for MI but also contributes a cutting-edge methodology to enhance the structural design of complex tissues for organ regeneration.

Indexed as

Myocardial InfarctionMyocardiumAnimalsBioengineeringMiceMyocytes, CardiacRegenerationTissue EngineeringTissue Scaffolds

Identifiers

PMID32637623
PMCPMC7314523

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.