ArticleScience advances2020
XAF1 as a modifier of p53 function and cancer susceptibility.
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Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
What it found
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Who cites it
38 citing papers in PubMed, 53 citations in OpenAlex.
- XAF1 nonsense mutation rs117407731 enhances lung adenocarcinoma susceptibility via apoptosis suppression.Molecular genetics and genomics : MGG · 2026Article
- Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance.NPJ genomic medicine · 2026Article
- Reconstructing the Origin and Demographic Expansion of the TP53 p.R337H Founder Variant in Brazil.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Identification of a GermlineHuman mutation · 2026Article
- Hyperoside Attenuates Lupus Nephritis-Associated Mesangial Cell Apoptosis via the P53/XAF1 Pathway: Integrative Bioinformatics and In Vitro Validation.Journal of inflammation research · 2026Article
- Deciphering dual clinical entities associated with TP53 pathogenic variants: Insights from 53,085 HBOC panel analyses in French laboratories.International journal of cancer · 2025Article
- Re-envisioning genetic predisposition to childhood and adolescent cancers.Nature reviews. Cancer · 2025Review
- Personalized screening strategies forLancet regional health. Americas · 2025Article
- Cancer risk in carriers of TP53 germline variants grouped into different functional categories.JNCI cancer spectrum · 2025Article
- Clustering ofiScience · 2024Article
- Current insights and future directions of Li-Fraumeni syndrome.Discover oncology · 2024Review
- AI-guided identification of risk variants for adrenocortical tumours inLancet regional health. Americas · 2024Article
- Pharmacological reactivation of p53 in the era of precision anticancer medicine.Nature reviews. Clinical oncology · 2024Review
- Prevalence and clinical implications of germline pathogenic variants in cancer predisposing genes in young patients across sarcoma subtypes.Journal of medical genetics · 2023Article
- Clinical and functional analysis of the germlineCold Spring Harbor molecular case studies · 2023Article
- Emerging insights into ethnic-specific TP53 germline variants.Journal of the National Cancer Institute · 2023Review
- Retrospective Analysis of Prognostic Factors in Pediatric Patients with Adrenocortical Tumor from Unique Tertiary Center with Long-Term Follow-Up.Journal of clinical medicine · 2022Review
- XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis.Acta diabetologica · 2022Article
- Applying precision medicine to the diagnosis and management of endocrine disorders.Endocrine connections · 2022Review
- XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity.Journal of virology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors at 20 institutions in 6 countries.
Emilia M PintoDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-5567-000X
Bonald C FigueiredoInstituto de Pesquisa Pelé Pequeno Principe, Curitiba, PR, Brazil.
Wenan ChenCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0379-2368
Henrique C R GalvaoHospital de Cancer de Barretos, Barretos, SP, Brazil.
Maria Nirvana FormigaA.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
Maria Candida B V FragosoSchool of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
Patricia Ashton-ProllaFederal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Enilze M S F RibeiroFederal University of Parana, Curitiba, PR, Brazil.
Gabriela FelixUniversidade Federal da Bahia, Salvador, BA, Brazil.
Tatiana E B CostaHospital Infantil Joana de Gusmao, Florianopolis, SC, Brazil.
Sharon A SavageNational Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-6006-0740
Meredith YeagerNational Cancer Institute, Rockville, MD, USA.
Edenir I PalmeroHospital de Cancer de Barretos, Barretos, SP, Brazil.
Sahlua VolcHospital de Cancer de Barretos, Barretos, SP, Brazil.ORCID 0000-0002-0577-6524
Hector SalvadorPediatric Oncology Department, Sant Joan de Deu Hospital, Barcelona, Spain.
Jose Luis Fuster-SolerHospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Cinzia LavarinoPediatric Oncology Department, Sant Joan de Deu Hospital, Barcelona, Spain.
Guillermo ChantadaDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA.
Dominique VaurComprehensive Cancer Center François Baclesse, Caen, France.
Vicente Odone-FilhoITACI-Instituto de Tratamento do Câncer Infantil do Departamento de Pediatria da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, SP, Brazil.
Laurence BrugièresInstitut Gustave Roussy, Villejuif, France.
Tobias ElseUniversity of Michigan, Ann Arbor, MI, USA.
Elena M StoffelUniversity of Michigan, Ann Arbor, MI, USA.
Kara N MaxwellPerelman School of Medicine University of Pennsylvania, Philadelphia, PA, USA.
Maria Isabel AchatzHospital Sírio-Libanes, Sao Paulo, SP, Brazil.
Luis KowalskiA.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
Kelvin C de AndradeNational Cancer Institute, Rockville, MD, USA.
Alberto PappoDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Eric LetouzeCentre de Recherche des Cordeliers, Paris, France.
Ana Claudia LatronicoSchool of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
Berenice B MendoncaSchool of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
Madson Q AlmeidaSchool of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
Vania B BrondaniSchool of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
Camila M BittarFederal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Emerson W S SoaresHospital do Câncer de Cascavel-UOPECCAN, Cascavel, PR, Brazil.ORCID 0000-0001-5756-2897
Carolina MathiasFederal University of Parana, Curitiba, PR, Brazil.
Cintia R N RamosHospital de Cancer de Barretos, Barretos, SP, Brazil.
Moara MachadoNational Cancer Institute, Rockville, MD, USA.
Weiyin ZhouNational Cancer Institute, Rockville, MD, USA.
Kristine JonesNational Cancer Institute, Rockville, MD, USA.
Aurelie VogtNational Cancer Institute, Rockville, MD, USA.
Payal P KlinchaNational Cancer Institute, Rockville, MD, USA.
Karina M SantiagoA.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
Heloisa KomechenInstituto de Pesquisa Pelé Pequeno Principe, Curitiba, PR, Brazil.
Mariana M ParaizoInstituto de Pesquisa Pelé Pequeno Principe, Curitiba, PR, Brazil.
Ivy Z S PariseInstituto de Pesquisa Pelé Pequeno Principe, Curitiba, PR, Brazil.
Kayla V HamiltonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jinling WangDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Evadnie RampersaudCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Michael R ClayDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Andrew J MurphyDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.
Enzo LalliInstitut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.ORCID 0000-0002-0584-5681
Kim E NicholsDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Raul C RibeiroDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Carlos Rodriguez-GalindoDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA.
Marta KorbonitsEndocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jinghui ZhangCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3350-9682
Mark G ThomasResearch Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000-0002-2452-981X
Jon P ConnellyCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shondra Pruett-MillerCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yoan DiekmannResearch Department of Genetics, Evolution and Environment, University College London, London, UK.
Geoffrey NealeHartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3776-0858
Gang WuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1678-5864
Gerard P ZambettiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0929-5007
St. Jude Children's Research Hospital · USNational Cancer Institute · USUniversidade de São Paulo · BRHospital de Câncer de Barretos · BRInstituto de Tecnologia do Paraná · BRAC Camargo Hospital · BRHospital Sant Joan de Déu Barcelona · ESUniversidade Federal do Paraná · BRUniversidade Federal do Rio Grande do Sul · BRUniversity College London · GBUniversity of Michigan · USCentre de Recherche des Cordeliers · FRCentre François Baclesse · LUHospital Infantil Joana de Gusmão · BRHospital Sírio-Libanês · BRHospital Universitario Virgen de la Arrixaca · ESInstitut de Pharmacologie Moléculaire et Cellulaire · FRInstitut Gustave Roussy · FRInstituto do Câncer do Estado de São Paulo · BRQueen Mary University of London · GB
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MClinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8MRapid Protease Profiling with a Multiplex Electronic Method for Detection of Metastatic Triple-Negative Breast CancerR01CA217657 · NCI · KANSAS STATE UNIVERSITY · PI LI, JUN · 2017 to 2020
$1.4MNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA217657
Abstract
Cancer risk is highly variable in carriers of the common
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.