ArticleScience advances2020
Lysosomal recycling of amino acids affects ER quality control.
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Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Heat stress reveals bidirectional cross talk between the heat shock response and UPRER in C. elegans.G3 (Bethesda, Md.) · 2026Article
- Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The Art of Domesticating Proteins: How Cancer Cells Adapt to Therapeutic and Environmental Stressors.International journal of molecular sciences · 2026Review
- The endoplasmic reticulum in mitochondrial protein targeting: A neuronal perspective on organelle crosstalk.Protein science : a publication of the Protein Society · 2026Review
- High-throughput multi-organ proteomics workflow for drug efficacy and toxicity analysis.Nature communications · 2026Article
- NoxO1 promotes endosome formation and reduces intracellular vesicle processing.Redox biology · 2026Article
- Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice.bioRxiv : the preprint server for biology · 2024Article
- The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle.Scientific reports · 2024Article
- MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress.The EMBO journal · 2024Article
- Simultaneous proteome localization and turnover analysis reveals spatiotemporal features of protein homeostasis disruptions.Nature communications · 2024Article
- Simultaneous proteome localization and turnover analysis reveals spatiotemporal features of protein homeostasis disruptions.bioRxiv : the preprint server for biology · 2024Article
- Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress.Molecular cancer research : MCR · 2023Article
- Role of amino acid metabolism in mitochondrial homeostasis.Frontiers in cell and developmental biology · 2023Review
- Primary cilia-mediated regulation of microglial secretion in Alzheimer's disease.Frontiers in molecular biosciences · 2023Article
- Fundamental roles for inter-organelle communication in aging.Biochemical Society transactions · 2022Review
- Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan.Neural regeneration research · 2022Article
- Picking the arginine lock on PQLC2 cycling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.Neurobiology of disease · 2021Review
Corrections and comments
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Authors and funding
21 authors.
Ryo Higuchi-SanabriaDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0001-8936-5812
Koning ShenDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0003-2607-449X
Naame KeletDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0001-7061-2975
Phillip A FrankinoDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0002-3909-3422
Jenni DurieuxDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0002-0016-7332
Raz Bar-ZivDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0003-2615-1942
Cierra N SingDepartment of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Enrique J GarciaDepartment of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Stefan HomentcovschiDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Melissa SanchezDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0002-4403-3977
Rui WuDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Sarah U TronnesDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0001-5357-046X
Larry JoeDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Brant WebsterDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Alex Ahilon-JeronimoDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Samira MonshietehadiDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0002-2910-7739
Sofia DallardaDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Corinne PenderDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0001-7092-3079
Liza A PonDepartment of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Roberto ZoncuDepartment of Biochemistry, Biophysics, and Structural Biology, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0003-1611-1891
Andrew DillinDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0002-7427-2629
Funding
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MMitochondrial inheritance and quality controlR35GM122589 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Liza A Pon · 2017 to 2026
$5.1MCell non-autonomous function of the unfolded protein responseR01AG042679 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2013 to 2017
$1.5MMolecular mechanisms for lipid sensing by mTORC1R01GM127763 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZONCU, ROBERTO · 2019 to 2022
$1.4MThe Role of Actin in Cellular AgingR33AG051047 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PON, LIZA A · 2018 to 2020
$1.4MSpatio-temporal regulation of mTORC1 signaling in normal and disease statesR01GM130995 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZONCU, ROBERTO · 2019 to 2022
$1.2MMore than just a load control: cytoskeletal form and function during agingR00AG065200 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIGUCHI-SANABRIA, RYO · 2021 to 2023
$747kMore than just a load control: cytoskeletal form and function during agingK99AG065200 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HIGUCHI-SANABRIA, RYO · 2020 to 2021
$244kMolecular and Therapeutic Mechanisms of a new model of Congenital Muscular DystrophyF31AR070013 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GARCIA, ENRIQUE JOSE · 2016 to 2019
$190kMitochondria-cytoskeleton communication and function in agingF31AG055326 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SING, CIERRA NICOLE · 2016 to 2020
$179kCell Non-Autonomous Regulation of NeuronalProteostasisF32AG065381 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI PENDER, CORINNE · 2019 to 2022
$176kNIAMS NIH HHS F31 AR070013NIA NIH HHS F31 AG055326NIA NIH HHS F32 AG065381NIA NIH HHS K99 AG065200NIA NIH HHS R00 AG065200NIA NIH HHS R01 AG042679NIA NIH HHS R33 AG051047NIA NIH HHS T32 AG000266NIGMS NIH HHS R01 GM127763NIGMS NIH HHS R01 GM130995NIGMS NIH HHS R35 GM122589NIH HHS P40 OD010440
Abstract
Recent work has highlighted the fact that lysosomes are a critical signaling hub of metabolic processes, providing fundamental building blocks crucial for anabolic functions. How lysosomal functions affect other cellular compartments is not fully understood. Here, we find that lysosomal recycling of the amino acids lysine and arginine is essential for proper ER quality control through the UPR
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.