ArticleGeriatric orthopaedic surgery & rehabilitation2020
Preoperative Anemia Treatment With Intravenous Iron in Patients Undergoing Major Orthopedic Surgery: A Systematic Review.
Article in Geriatric orthopaedic surgery & rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Review of the influence of anaemia on the effect of total hip arthroplasty, and the prognosis of patients: recent advances and future directions.Annals of medicine · 2026Review
- Perioperative Anemia and Transfusion Management in Older Adults with Osteoporotic Hip Fractures: A Narrative Review of Current Evidence and Emerging Strategies.Clinical interventions in aging · 2026Review
- Impact of Iron Deficiency Anemia on Postoperative Outcomes of Thoracolumbar Spinal Fusion (2+ levels) on Patients with Adult Spinal Deformity with Minimum 2-Year Follow-Up.Spine surgery and related research · 2025Article
- "Detect Anemia Preoperatively": A Scoping Review of Recommendations.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Review
- Interventions for reducing red blood cell transfusion in adults undergoing hip fracture surgery: an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Review
- Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery.BMC geriatrics · 2023Observational
- Anemia and formation of deep vein thrombosis before operation in patients with knee osteoarthritis: a cross-sectional study.Journal of orthopaedic surgery and research · 2023Article
- CONTEMPORARY RECOMMENDATIONS ON PATIENT BLOOD MANAGEMENT IN JOINT ARTHROPLASTY.Acta clinica Croatica · 2022Review
- Unexplained anemia of aging: Etiology, health consequences, and diagnostic criteria.Journal of the American Geriatrics Society · 2022Review
- Cerebral Hypoxia: Its Role in Age-Related Chronic and Acute Cognitive Dysfunction.Anesthesia and analgesia · 2021Review
- Association between intravenous iron therapy and short-term mortality risk in older patients undergoing hip fracture surgery: an observational study.Journal of orthopaedic surgery and research · 2021Observational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBased upon the Third National Health and Nutrition Examination Survey data, iron deficiency anemia is the cause of at least 20% of cases of anemia in adults over the age of 65. This is especially relevant in patients undergoing major orthopedic surgery as substantial perioperative blood loss is possible, leading to a high rate of allogeneic blood transfusion in total hip replacements, total knee replacements, and hip fracture repairs. SIGNIFICANCE: The results of this systematic review may be of interest to clinicians and hospital administrators evaluating the clinical efficacy and cost effectiveness of intravenous (IV) iron administration prior to major orthopedic surgery. MATERIALS AND
methodsThe original studies considered for this review included patients who were over 18 years of age, undergoing major orthopedic surgery, and who received an IV iron treatment in the preoperative setting. A total of 1083 articles were identified and reviewed. After removing duplicates, 1031 publications were screened, and 105 full-text studies were assessed for eligibility. A total of 98 were excluded and 7 articles remained which met the criteria for this review. The primary outcome examined in the included studies was the allogeneic blood transfusion rate. The secondary areas of interest were changes in serum hemoglobin, morbidity and mortality, length of stay, and cost effectiveness.
resultsThis systematic review found little evidence that IV iron therapy is effective at reducing transfusion in patients undergoing major orthopedic surgery.
conclusionsWe do not recommend preoperative IV iron therapy for all patients scheduled for major orthopedic surgery.
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