ReviewArrhythmia & electrophysiology review2020
The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context.
Review in Arrhythmia & electrophysiology review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04704986 (Comparison of the PolarX and the Arctic Front Cryoballoon for Pulmonary Vein Isolation in Patients With Symptomatic Paroxysmal Atrial Fibrillation - A Multi-Center Non-Inferiority Design Clinical Trial), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the PolarX and the Arctic Front Cryoballoon for Pulmonary Vein Isolation in Patients With Symptomatic Paroxysmal Atrial Fibrillation - A Multi-Center Non-Inferiority Design Clinical Trial
Who cites it
13 citing papers in PubMed, 1 citations in OpenAlex.
- Atrial Fibrillation Burden: Assessment, Clinical Significance, and Therapeutic Implications.Life (Basel, Switzerland) · 2026Review
- Multicenter analysis of device-detected atrial fibrillation burden reduction after antiarrhythmic drug initiation.Heart rhythm O2 · 2026Article
- Does cryoballoon ablation affect the symptom severity of atrial fibrillation? Insights from 12-months continuous cardiac monitoring.BMC cardiovascular disorders · 2025Observational
- Do depressive and anxiety symptoms influence the quality of life of patients with atrial fibrillation after cryoballoon ablation: a comparison study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Characterization of durability and reconnection patterns at time of repeat ablation after single-shot pulsed field pulmonary vein isolation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Validation of the SCALE-CryoAF risk model to predict very late return of atrial fibrillation after cryoballoon ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Pulsed field ablation in real-world atrial fibrillation patients: clinical recurrence, operator learning curve and re-do procedural findings.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Can we predict success when failure is obscured?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Posterior wall isolation in persistent atrial fibrillation. Long-term outcomes of a repeat procedure strategy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Clinical and Structural Factors Affecting Ablation Outcomes in Atrial Fibrillation Patients - A Review.Current cardiology reviews · 2023Review
- Posterior wall isolation in persistent atrial fibrillation feasibility, safety, durability, and efficacy.Journal of cardiovascular electrophysiology · 2022Article
- Catheter Ablation as First-Line Therapy in the Treatment of Atrial Fibrillation - Should We Always Indicate it?Arquivos brasileiros de cardiologia · 2022Article
- Effect of pulmonary vein cryoballoon ablation in dogs with coolant-nitrogen.Journal of thoracic disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation: Double Short vs Standard Exposure Duration (CIRCA-DOSE) study was a multicentre, randomised, single-blinded trial that compared contact-force radiofrequency ablation and two different regimens of cryoballoon ablation. All patients received an implantable cardiac monitor for the purpose of continuous rhythm monitoring, with all arrhythmia events undergoing independent adjudication by a committee blinded to treatment allocation. The study demonstrated there were no significant differences between contact-force radiofrequency ablation and cryoballoon ablation with respect to recurrence of any atrial tachyarrhythmia, symptomatic atrial tachyarrhythmia, asymptomatic AF, symptomatic AF or AF burden. While the results of the CIRCA-DOSE study are reviewed here, this article focuses on considerations around the design of the study and places the observed outcomes in context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.