ArticleComputational and structural biotechnology journal2020
Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics.
Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Azobenzene-Based Photoswitchable Substrates for Advanced Mechanistic Studies of Model Haloalkane Dehalogenase Enzyme Family.ACS catalysis · 2024Article
- Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures.ACS sustainable chemistry & engineering · 2024Article
- Preparation and Characterization of an Ancient Aminopeptidase Obtained from Ancestral Sequence Reconstruction for L-Carnosine Synthesis.Molecules (Basel, Switzerland) · 2022Article
- Engineering and characterization of dehalogenase enzymes fromSynthetic and systems biotechnology · 2022Article
- Structural Analysis of the Ancestral Haloalkane Dehalogenase AncLinB-DmbA.International journal of molecular sciences · 2021Article
- Mini Review: Advances in 2-Haloacid Dehalogenases.Frontiers in microbiology · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Ancestral sequence reconstruction is a powerful method for inferring ancestors of modern enzymes and for studying structure-function relationships of enzymes. We have previously applied this approach to haloalkane dehalogenases (HLDs) from the subfamily HLD-II and obtained thermodynamically highly stabilized enzymes (Δ
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