Evidence map›Paper›PMID 32636945›Full record

ArticleTherapeutic advances in musculoskeletal disease2020

Dual-energy computed-tomography-based discrimination between basic calcium phosphate and calcium pyrophosphate crystal deposition

Tristan Pascart, Guillaume Falgayrac, Laurène Norberciak, Clément Lalanne, Julie Legrand, Eric Houvenagel, Hang-Korng Ea, Fabio Becce, Jean-François Budzik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in musculoskeletal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Advanced imaging techniques in crystal arthritis.Therapeutic advances in musculoskeletal disease · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Computed tomography-current status and future directions for arthritis imaging.Therapeutic advances in musculoskeletal disease · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Periarticular calcifications.Skeletal radiology · 2022
    Review
  15. Imaging of Joints and Bones in Autoinflammation.Journal of clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tristan PascartDepartment of Rheumatology, Lille Catholic Hospitals, Saint-Philibert Hospital, University of Lille, Rue du Grand But, Lomme, F-59160, France.ORCID https://orcid.org/0000-0002-8395-826X
Guillaume FalgayracEA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, University of Lille, Lille, France.
Laurène NorberciakDepartment of Medical Research, Biostatistics, Lille Catholic Hospitals, University of Lille, Lomme, France.
Clément LalanneDepartment of Orthopaedic Surgery, Lille Catholic Hospitals, University of Lille, Lomme, France.
Julie LegrandDepartment of Diagnostic and Interventional Radiology, Lille Catholic Hospitals, University of Lille, Lomme, France.
Eric HouvenagelDepartment of Rheumatology, Lille Catholic Hospitals, University of Lille, Lomme, France.
Hang-Korng EaDepartment of Rheumatology, Hôpital Lariboisière, AP-HP, Paris, France.
Fabio BecceDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-8444-8504
Jean-François BudzikEA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, University of Lille, Lille, France.
Université Catholique de Lille · FRUniversité de Lille · FRInserm · FRUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDual-energy computed tomography (DECT) is being considered as a non-invasive diagnostic and characterization tool in calcium crystal-associated arthropathies. Our objective was to assess the potential of DECT in distinguishing between basic calcium phosphate (BCP) and calcium pyrophosphate (CPP) crystal deposition in and around joints

methodsA total of 13 patients with calcific periarthritis and 11 patients with crystal-proven CPPD were recruited prospectively to undergo DECT scans. Samples harvested from BCP and CPP calcification types were analyzed using Raman spectroscopy and validated against synthetic crystals. Regions of interest were placed in BCP and CPP calcifications, and the following DECT attenuation parameters were obtained: CT numbers (HU) at 80 and 140 kV, dual-energy index (DEI), electron density (Rho), and effective atomic number (

resultsRaman spectroscopy enabled chemical fingerprinting of BCP and CPP crystals both

conclusionDECT can help distinguish between crystal-proven BCP and CPP calcification types

Indexed as

basic calcium phosphatecalcium hydroxyapatitecalcium pyrophosphatecrystal-associated arthropathiesdual-energy computed tomographyRaman spectroscopy

Identifiers

PMID32636945
PMCPMC7315653
OpenAlexW3037050643

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.