Evidence map›Paper›PMID 32636846›Full record

ArticleFrontiers in immunology2020

Toll-Like Receptor Ligand Based Adjuvant, PorB, Increases Antigen Deposition on Germinal Center Follicular Dendritic Cells While Enhancing the Follicular Dendritic Cells Network.

Christina Lisk, Rachel Yuen, Jeff Kuniholm, Danielle Antos, Michael L Reiser, Lee M Wetzler

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Germinal Centre Shutdown.Frontiers in immunology · 2021
    Review
  13. Article
  14. CirculatingIn vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Christina LiskSection of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA, United States.
Rachel YuenDepartment of Microbiology, Boston University School of Medicine, Boston, MA, United States.
Jeff KuniholmDepartment of Microbiology, Boston University School of Medicine, Boston, MA, United States.
Danielle AntosDepartment of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Michael L ReiserDRK-Blutspendedienst, BaWü-Hessen gGmbH, Frankfurt, Germany.
Lee M WetzlerSection of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA, United States.
Boston Medical Center · USBoston University · USDRK-Blutspendedienst Baden-Württemberg - Hessen · DEUniversity of Pittsburgh · US

Funding

Neisserial Porins and Antigen Presenting CellsR01AI040944 · NIAID · BOSTON MEDICAL CENTER · PI WETZLER, LEE MARK · 1997 to 2019
$9.3M
NIAID NIH HHS R01 AI040944
6 · The paper itself

Abstract

Vaccines are arguably one of the greatest advancements in modern medicine. Subunit vaccines comprise the majority of current preparations and consist of two main components-antigen and adjuvant. The antigen is a small molecule against which the vaccine induces an immune response to provide protection via the immunostimulatory ability of the adjuvant. Our laboratory has investigated the adjuvant properties of Toll-like receptor (TLR) ligand-based adjuvants, especially the outer membrane protein from

Indexed as

Adjuvants, ImmunologicAnimalsB-LymphocytesDendritic Cells, FollicularFemaleGerminal CenterMaleMiceMice, Inbred C57BLOvalbuminPorinsVaccinationVaccinesAdjuvants, ImmunologicOvalbuminporin protein, NeisseriaPorinsVaccinesadjuvantsantigen depositiondendritic cellsfollicular dendritic cellsneisseriaPorBTLR2TLR-ligand based adjuvants

Identifiers

PMID32636846
PMCPMC7318107
OpenAlexW3036424263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.