ArticleTurkish journal of pharmaceutical sciences2020
Pyrophen Isolated from the Endophytic Fungus
Article in Turkish journal of pharmaceutical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Taxonomy, metabolite diversity and antimicrobial activity of Tectaria coadunata (J.Sm.) C.Chr. fungal endophytes.Archives of microbiology · 2026Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPyrophen, an amino acid-pyrone derivative isolated from MATERIALS AND
methodsThe cytotoxicity of pyrophen and Dox separately and in combination were evaluated in T47D and MCF-7 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Modulation of cell cycle distribution and apoptosis was examined by flow cytometry.
resultsOur findings showed that pyrophen did not significantly potentiate Dox-induced cytotoxicity in T47D cells. Adding Dox-treated T47D cells with pyrophen at a concentration of 9.20 μg/mL induced a slight increase in the S-phase cell population. This compound induced cytotoxicity of MCF-7 cells with IC
conclusionThe data suggest different mechanisms of regulation in promoting cell death by two different cell lines in response to administration of pyrophen.
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