Tetramethylpyrazine protects mice retinas against sodium iodate-induced oxidative injury.

Jie Huang, Yan Liu, Ke Mao, Qing Gu, Xingwei Wu

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In one paragraph

Article in Molecular vision, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Human Pluripotent Stem Cells Derived Endothelial Cells Repair Choroidal Ischemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jie HuangDepartment of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.

Yan LiuDepartment of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.

Ke MaoDepartment of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.

Qing GuDepartment of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.

Xingwei WuDepartment of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.

Shanghai First People's Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To observe the effects of tetramethylpyrazine (TMP) on mice retinas injured by sodium iodate (NaIO Methods: Male mice (n = 45) were randomly divided into three groups: the control group (Group C), the NaIO Results: TMP effectively prevented the decrease in the thicknesses of the retinas and the outer nuclear layer (ONL), and effectively alleviated the functional decline in the retinas after NaIO Conclusions: TMP alleviates morphological and functional retinal damage in mice exposed to NaIO

Indexed as

AnimalsApoptosisbcl-2-Associated X ProteinDisease Models, AnimalElectroretinographyEpithelial CellsGene Expression RegulationHeme Oxygenase-1Injections, IntraperitonealIodatesMacular DegenerationMaleMembrane ProteinsMiceMice, Inbred C57BLNF-E2-Related Factor 2Bax protein, mousebcl-2-Associated X ProteinHeme Oxygenase-1Hmox1 protein, mouseIodatesMembrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2Protective AgentsPyrazinessodium iodatetetramethylpyrazine

Identifiers

PMID32636604

PMCPMC7324667

OpenAlexW3041778656

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.