ArticleScientific reports2020
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Role of extended-spectrum β-lactamase (ESBL) genes in the dissemination of β-lactam resistance within aquatic environments: mechanisms, persistence, and one health implications.World journal of microbiology & biotechnology · 2026Review
- Genetic traits of IncK2 plasmids and theMicrobial genomics · 2026Article
- DecipheringPathogens (Basel, Switzerland) · 2025Article
- Prevalence of ESBL-Resistant Genes in Birds in Italy-A Comprehensive Review.Animals : an open access journal from MDPI · 2025Review
- Progression ofmBio · 2025Article
- Development, validation, and application of SYBR green-based qPCR assays for detection and quantification ofFrontiers in veterinary science · 2025Article
- Mapping the spread of fluoroquinolone resistance: continued presence of non-susceptibleFrontiers in veterinary science · 2025Article
- Extended-spectrum β-lactamase-producingVeterinary world · 2024Review
- Persistence of commensal multidrug-resistantFrontiers in microbiology · 2024Article
- Article
- Biofilm Formation Ability of ESBL/pAmpC-ProducingAntibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial resistance, virulence associated genes and phylogenetic background versus plasmid replicon types: the possible associations in avian pathogenic Escherichia coli (APEC).BMC veterinary research · 2022Article
- Amoxicillin and thiamphenicol treatments may influence the co-selection of resistance genes in the chicken gut microbiota.Scientific reports · 2022Article
- Assessing the Load, Virulence and Antibiotic-Resistant Traits of ESBL/AmpcAntibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- High-Frequency Detection ofFrontiers in microbiology · 2022Article
- Multi-Drug Resistant Plasmids with ESBL/AmpC andMicroorganisms · 2021Article
- Prevalence and antimicrobial resistance ofJournal of veterinary science · 2021Article
- Occurrence of Colibacillosis in Broilers and Its Relationship With Avian PathogenicFrontiers in veterinary science · 2021Article
- Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-ProducingFrontiers in microbiology · 2021Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of extended-spectrum β-lactamase (ESBL) or plasmid-mediated AmpC β-lactamase (pAmpC)-producing Escherichia coli (ESBL/pAmpC-EC) in livestock is a public health risk given the likelihood of their transmission to humans via the food chain. We conducted whole genome sequencing on 100 ESBL/pAmpC-EC isolated from the broiler production to explore their resistance and virulence gene repertoire, characterise their plasmids and identify transmission events derived from their phylogeny. Sequenced isolates carried resistance genes to four antimicrobial classes in addition to cephalosporins. Virulence gene analysis assigned the majority of ESBL/pAmpC-EC to defined pathotypes. In the complex genetic background of ESBL/pAmpC-EC, clusters of closely related isolates from various production stages were identified and indicated clonal transmission. Phylogenetic comparison with publicly available genomes suggested that previously uncommon ESBL/pAmpC-EC lineages could emerge in poultry, while others might contribute to the maintenance and dissemination of ESBL/pAmpC genes in broilers. The majority of isolates from diverse E. coli lineages shared four dominant plasmids (IncK2, IncI1, IncX3 and IncFIB/FII) with identical ESBL/pAmpC gene insertion sites. These plasmids have been previously reported in diverse hosts, including humans. Our findings underline the importance of specific plasmid groups in the dissemination of cephalosporin resistance genes within the broiler industry and across different reservoirs.
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