Evidence map›Paper›PMID 32636372›Full record

ArticleNature communications2020

Discovery and population genomics of structural variation in a songbird genus.

Matthias H Weissensteiner, Ignas Bunikis, Ana Catalán, Kees-Jan Francoijs, Ulrich Knief, Wieland Heim, Valentina Peona, Saurabh D Pophaly, Fritz J Sedlazeck, Alexander Suh and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Matthias H WeissensteinerDepartment of Evolutionary Biology and Science for Life Laboratory, Uppsala University, 752 36, Uppsala, Sweden. mh.weissensteiner@gmail.com.ORCID http://orcid.org/0000-0001-9302-798X
Ignas BunikisUppsala Genome Center, Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, BMC, Box 815, 752 37, Uppsala, Sweden.
Ana CatalánDivision of Evolutionary Biology, Faculty of Biology, LMU Munich, Grosshaderner Str. 2, 82152, Planegg-Martinsried, Germany.
Kees-Jan FrancoijsBioNanoGenomics, San Diego, CA, 92121, USA.
Ulrich KniefDivision of Evolutionary Biology, Faculty of Biology, LMU Munich, Grosshaderner Str. 2, 82152, Planegg-Martinsried, Germany.ORCID http://orcid.org/0000-0001-6959-3033
Wieland HeimInstitute of Landscsape Ecology, University of Münster, Heisenbergstrasse 2, 48149, Münster, Germany.ORCID http://orcid.org/0000-0002-3262-2491
Valentina PeonaDepartment of Evolutionary Biology and Science for Life Laboratory, Uppsala University, 752 36, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-5119-1837
Saurabh D PophalyDivision of Evolutionary Biology, Faculty of Biology, LMU Munich, Grosshaderner Str. 2, 82152, Planegg-Martinsried, Germany.
Fritz J SedlazeckHuman Genome Sequencing Center at Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Alexander SuhDepartment of Evolutionary Biology and Science for Life Laboratory, Uppsala University, 752 36, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-8979-9992
Vera M WarmuthDivision of Evolutionary Biology, Faculty of Biology, LMU Munich, Grosshaderner Str. 2, 82152, Planegg-Martinsried, Germany.
Jochen B W WolfDepartment of Evolutionary Biology and Science for Life Laboratory, Uppsala University, 752 36, Uppsala, Sweden. j.wolf@biologie.uni-muenchen.de.

Funding

Genomic Architecture of Common Disease in Diverse Populations: WGS of Ongoing Hemorrhagic Stroke Study SupplementUM1HG008898 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2016 to 2020
$77.0M
NHGRI NIH HHS UM1 HG008898
6 · The paper itself

Abstract

Structural variation (SV) constitutes an important type of genetic mutations providing the raw material for evolution. Here, we uncover the genome-wide spectrum of intra- and interspecific SV segregating in natural populations of seven songbird species in the genus Corvus. Combining short-read (N = 127) and long-read re-sequencing (N = 31), as well as optical mapping (N = 16), we apply both assembly- and read mapping approaches to detect SV and characterize a total of 220,452 insertions, deletions and inversions. We exploit sampling across wide phylogenetic timescales to validate SV genotypes and assess the contribution of SV to evolutionary processes in an avian model of incipient speciation. We reveal an evolutionary young (~530,000 years) cis-acting 2.25-kb LTR retrotransposon insertion reducing expression of the NDP gene with consequences for premating isolation. Our results attest to the wealth and evolutionary significance of SV segregating in natural populations and highlight the need for reliable SV genotyping.

Indexed as

Genetics, PopulationGenetic VariationAnimalsChromosome InversionGene DeletionGenomeGenomic Structural VariationGenotypePhylogenyPolymorphism, Single NucleotideRetroelementsSequence Analysis, DNASongbirdsRetroelements

Identifiers

PMID32636372
PMCPMC7341801

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.