Evidence map›Paper›PMID 32636323›Full record

ArticleNeurology2020

Temporal trends and autopsy findings of SUDEP based on medico-legal investigations in the United States.

Esma Cihan, Orrin Devinsky, Dale C Hesdorffer, Michael Brandsoy, Ling Li, David R Fowler, Jason K Graham, Michael W Karlovich, Jaclyn E Yang, Anne E Keller and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  10. Brugada Syndrome: Warning of a Systemic Condition?Frontiers in cardiovascular medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Esma CihanFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.ORCID 0000-0003-1030-2101
Orrin DevinskyFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.ORCID 0000-0003-0044-4632
Dale C HesdorfferFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.ORCID 0000-0003-1783-5381
Michael BrandsoyFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
Ling LiFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
David R FowlerFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
Jason K GrahamFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
Michael W KarlovichFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
Jaclyn E YangFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
Anne E KellerFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
Elizabeth J DonnerFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada.
Daniel FriedmanFrom the Department of Neurology (E.C., O.D., M.W.K., J.E.Y., D.F.), NYU School of Medicine; Department of Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY; San Diego County Medical Examiner's Office (M.B.), CA; Maryland Office of the Chief Medical Examiner (L.L., D.R.F.), Baltimore; New York City Office of Chief Medical Examiner (J.K.G.), New York; and Division of Neurology, Department of Paediatrics (A.E.K., E.J.D.), the Hospital for Sick Children, Toronto, Canada. Daniel.Friedman@nyulangone.org.ORCID 0000-0003-1068-1797
Office of Chief Medical Examiner · US

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
NCATS NIH HHS UL1 TR001445
6 · The paper itself

Abstract

objectiveTo determine time trends and distinguishing autopsy findings of sudden unexpected death in epilepsy (SUDEP) in the United States.

methodsWe identified decedents where epilepsy/seizure was listed as cause/contributor to death or comorbid condition on the death certificate among all decedents who underwent medico-legal investigation at 3 medical examiner (ME) offices across the country: New York City (2009-2016), San Diego County (2008-2016), and Maryland (2000-2016). After reviewing all available reports, deaths classified as definite/probable/near SUDEP or SUDEP plus were included for analysis. Mann-Kendall trend test was used to analyze temporal trends in SUDEP rate for 2009-2016. Definite SUDEPs were compared to sex- and age ±2 years-matched non-SUDEP deaths with a history of epilepsy regarding autopsy findings, circumstances, and comorbidities.

resultsA total of 1,086 SUDEP cases were identified. There was a decreasing trend in ME-investigated SUDEP incidence between 2009 and 2016 (

conclusionsThere was a decreasing monotonic trend in ME-investigated SUDEP incidence over 8 years, with a 28% reduction in incidence from 2009-2012 to 2013-2016. Unlike SIDS and sudden cardiac death, we found no correlation between SUDEP and the season of year or day of week. No autopsy findings distinguished SUDEP from non-SUDEP deaths.

Indexed as

AdolescentAdultAgedAged, 80 and overCause of DeathChildChild, PreschoolComorbidityDeath, SuddenEpilepsyFemaleHumansIncidenceInfantMaleMiddle Aged

Identifiers

PMID32636323
PMCPMC7605498
OpenAlexW3042202258

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.