ArticleProceedings of the National Academy of Sciences of the United States of America2020
Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Enhancing sleep slow waves with auditory stimulation in people with Parkinson's disease: a randomized proof-of-concept trial.Scientific reports · 2026Trial
- Low-Frequency Deep Brain Stimulation in Non-Rapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Pathophysiology and pharmacological management for sleep problems in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Entrained cortical delta-spindle activity, not periodic synchrony, prevents arousal by NREM thalamic bursts.Communications biology · 2026Article
- Personalized supervised and unsupervised intracranial sleep decoding during deep brain stimulation.NPJ digital medicine · 2026Article
- Excessive daytime sleepiness in parkinsonism is associated with cortical and basal ganglia beta oscillatory activity.Communications biology · 2026Article
- AnFrontiers in computational neuroscience · 2026Article
- Emerging neurotechnological approaches to management of sleep disturbances in Parkinson's disease.Clinical parkinsonism & related disorders · 2026Review
- Sharp Waves, Bursts, and Coherence: Activity in a Songbird Vocal Circuit Is Influenced by Behavioral State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A clinical grade neurostimulation implant for hierarchical control of physiological activity.bioRxiv : the preprint server for biology · 2025Article
- From adaptive deep brain stimulation to adaptive circuit targeting.Nature reviews. Neurology · 2025Review
- Article
- Toward an Automatic Classification of the Different Stages of Sleep: Exploring Patterns of Neural Activity in the Subthalamic Nucleus.The European journal of neuroscience · 2025Article
- Insomnia in Parkinson's Disease: Causes, Consequences, and Therapeutic Approaches.Molecular neurobiology · 2025Review
- Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation.NPJ Parkinson's disease · 2025Review
- The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson's disease.Nature communications · 2024Article
- Slow-wave sleep dysfunction in mild parkinsonism is associated with excessive beta and reduced delta oscillations in motor cortex.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep disorders are among the most debilitating comorbidities of Parkinson's disease (PD) and affect the majority of patients. Of these, the most common is insomnia, the difficulty to initiate and maintain sleep. The degree of insomnia correlates with PD severity and it responds to treatments that decrease pathological basal ganglia (BG) beta oscillations (10-17 Hz in primates), suggesting that beta activity in the BG may contribute to insomnia. We used multiple electrodes to record BG spiking and field potentials during normal sleep and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism in nonhuman primates. MPTP intoxication resulted in severe insomnia with delayed sleep onset, sleep fragmentation, and increased wakefulness. Insomnia was accompanied by the onset of nonrapid eye movement (NREM) sleep beta oscillations that were synchronized across the BG and cerebral cortex. The BG beta oscillatory activity was associated with a decrease in slow oscillations (0.1-2 Hz) throughout the cortex, and spontaneous awakenings were preceded by an increase in BG beta activity and cortico-BG beta coherence. Finally, the increase in beta oscillations in the basal ganglia during sleep paralleled decreased NREM sleep, increased wakefulness, and more frequent awakenings. These results identify NREM sleep beta oscillation in the BG as a neural correlate of PD insomnia and suggest a mechanism by which this disorder could emerge.
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