Evidence map›Paper›PMID 32636248›Full record

ArticlemBio2020

Epitope Shaving Promotes Fungal Immune Evasion.

Delma S Childers, Gabriela Mol Avelar, Judith M Bain, Arnab Pradhan, Daniel E Larcombe, Mihai G Netea, Lars P Erwig, Neil A R Gow, Alistair J P Brown

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
1.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 76 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. International journal of molecular sciences · 2026
    Article
  5. Article
  6. Loss of Fgr41 inInfection and immunity · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Computational Approaches for Discovering Virulence Factors inJournal of fungi (Basel, Switzerland) · 2025
    Review
  12. Article
  13. Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Journal of proteome research · 2025
    Article
  15. Article
  16. Frontiers in cellular and infection microbiology · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Delma S ChildersAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom delma.childers@abdn.ac.uk a.j.p.brown@exeter.ac.uk.
Gabriela Mol AvelarAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Judith M BainAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Arnab PradhanAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Daniel E LarcombeAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
Lars P ErwigAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Neil A R GowAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.ORCID 0000-0002-2776-5850
Alistair J P BrownAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom delma.childers@abdn.ac.uk a.j.p.brown@exeter.ac.uk.ORCID 0000-0003-1406-4251
University of Aberdeen · GBUniversity of Bonn · DE

Funding

Medical Research Council MR/M026663/1Medical Research Council MR/M026663/2Medical Research Council MR/N006364/1Medical Research Council MR/N006364/2Wellcome TrustWellcome Trust 075470Wellcome Trust 086827Wellcome Trust 093378Wellcome Trust 097377Wellcome Trust 099197Wellcome Trust 101873Wellcome Trust 102705Wellcome Trust 200208
6 · The paper itself

Abstract

The cell wall provides a major physical interface between fungal pathogens and their mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival. Fungus-specific cell wall moieties, such as β-1,3-glucan, are recognized as pathogen-associated molecular patterns (PAMPs) that activate immune-mediated clearance mechanisms. We have reported that the opportunistic human fungal pathogen

Indexed as

Immune EvasionAnaerobiosisAnimalsCandida albicansCellulose 1,4-beta-CellobiosidaseEpitopesLactic AcidLarvaMacrophagesMaleMetabolic Networks and PathwaysMiceMice, Inbred C57BLMothsCellulose 1,4-beta-CellobiosidaseEpitopesLactic AcidCandida albicanscastanosperminecell wallimmune evasionvirulenceXog1 exoglucanaseβ-glucan shaving

Identifiers

PMID32636248
PMCPMC7343991
OpenAlexW3039859690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.