Evidence map›Paper›PMID 32636244›Full record

ArticlemBio2020

Toxoplasma gondii Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells.

Leonardo Augusto, Jennifer Martynowicz, Parth H Amin, Nada S Alakhras, Mark H Kaplan, Ronald C Wek, William J Sullivan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Toxoplasma-host endoplasmic reticulum interaction: HowCurrent research in microbial sciences · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Manipulation of Host Cell Organelles by Intracellular Pathogens.International journal of molecular sciences · 2021
    Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Leonardo AugustoDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jennifer MartynowiczDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Parth H AminDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Nada S AlakhrasDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Mark H KaplanDepartment of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ronald C WekDepartment of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA rwek@iu.edu wjsulliv@iu.edu.
William J SullivanDepartment of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA rwek@iu.edu wjsulliv@iu.edu.ORCID 0000-0003-1823-8642
Indiana University School of Medicine

Funding

Immunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0M
Translational control during stage conversion of Toxoplasma, an opportunistic infection of HIV/AIDSR01AI124723 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI SULLIVAN, WILLIAM J, WEK, RONALD C · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI124723NIAID NIH HHS T32 AI060519
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell MovementHost-Pathogen InteractionsUnfolded Protein ResponseAnimalsCalciumCells, CulturedEndoplasmic ReticulumEndoplasmic Reticulum StressFibroblastsMembrane ProteinsMiceProtein Serine-Threonine KinasesToxoplasmaToxoplasmosisCalciumErn2 protein, mouseMembrane ProteinsProtein Serine-Threonine Kinasescell migrationfilamin Ahost-pathogen interactionsIRE1parasitespathogenesisPERKToxoplasmaUPR

Identifiers

PMID32636244
PMCPMC7343987
OpenAlexW3038793079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.