Evidence map›Paper›PMID 32636099›Full record

Trial reportEuropean urology2020

Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial).

Beatriz Goulao, Sonya Carnell, Jing Shen, Graeme MacLennan, John Norrie, Jonathan Cook, Elaine McColl, Matt Breckons, Luke Vale, Paul Whybrow and 12 more

Open access · greenAbstract readComparative StudyRandomized Controlled TrialEquivalence Trial
PubMed Publisher
In one paragraph

Trial report in European urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Drug-Coated Balloon (OptilumeAdvances in urology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. [Urethral reconstruction].Urologie (Heidelberg, Germany) · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. The evolution of urethral stricture and urethroplasty practice over 15 years: A single-center, single-surgeon, 1319 urethroplasty analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022
    Article
  16. Article
  17. Review
  18. Round up.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
  19. Round up.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 1 country.

Beatriz GoulaoHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.
Sonya CarnellNewcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK.
Jing ShenInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Graeme MacLennanCentre for Healthcare and Randomised Trials, University of Aberdeen, Aberdeen, UK.
John NorrieEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Jonathan CookCentre for Statistics in Medicine, University of Oxford, Oxford, UK.
Elaine McCollInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Matt BreckonsInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Luke ValeInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK. Electronic address: luke.vale@ncl.ac.uk.
Paul WhybrowHull York Medical School, University of Hull, Hull, UK.
Tim RapleySocial Work, Education and Community Wellbeing, University of Northumbria, Newcastle upon Tyne, UK.
Rebecca ForbesNewcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK.
Stephanie CurrerNewcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK.
Mark ForrestCentre for Healthcare and Randomised Trials, University of Aberdeen, Aberdeen, UK.
Jennifer WilkinsonNewcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK.
Daniela AndrichUniversity College London Hospital, London, UK.
Stewart BarclayNewcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Anthony MundyUniversity College London Hospital, London, UK.
James N'DowAcademic Urology Unit, University of Aberdeen, Aberdeen, UK.
Stephen PayneCentral Manchester Hospitals NHS Foundation Trust, Manchester, UK.
Nick WatkinSt George's University Hospitals NHS Foundation Trust, London, UK.
Robert PickardInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Newcastle University · GBUniversity of Aberdeen · GBUniversity College Hospital · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBNorthumbria University · GBSt George’s University Hospitals NHS Foundation Trust · GBUniversity of Edinburgh · GBUniversity of Hull · GBUniversity of Oxford · GB

Funding

Chief Scientist Office HSRU1Medical Research Council MR/K02325X/1
6 · The paper itself

Abstract

backgroundUrethral stricture affects 0.9% of men. Initial treatment is urethrotomy. Approximately, half of the strictures recur within 4 yr. Options for further treatment are repeat urethrotomy or open urethroplasty.

objectiveTo compare the effectiveness and cost-effectiveness of urethrotomy with open urethroplasty in adult men with recurrent bulbar urethral stricture. DESIGN, SETTING, AND

participantsThis was an open label, two-arm, patient-randomised controlled trial. UK National Health Service hospitals were recruited and 222 men were randomised to receive urethroplasty or urethrotomy.

interventionUrethrotomy is a minimally invasive technique whereby the narrowed area is progressively widened by cutting the scar tissue with a steel blade mounted on a urethroscope. Urethroplasty is a more invasive surgery to reconstruct the narrowed area. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary outcome was the profile over 24 mo of a patient-reported outcome measure, the voiding symptom score. The main clinical outcome was time until reintervention. RESULTS AND LIMITATIONS: The primary analysis included 69 (63%) and 90 (81%) of those allocated to urethroplasty and urethrotomy, respectively. The mean difference between the urethroplasty and urethrotomy groups was -0.36 (95% confidence interval [CI] -1.74 to 1.02). Fifteen men allocated to urethroplasty needed a reintervention compared with 29 allocated to urethrotomy (hazard ratio [95% CI] 0.52 [0.31-0.89]).

conclusionsIn men with recurrent bulbar urethral stricture, both urethroplasty and urethrotomy improved voiding symptoms. The benefit lasted longer for urethroplasty. PATIENT SUMMARY: There was uncertainty about the best treatment for men with recurrent bulbar urethral stricture. We randomised men to receive one of the following two treatment options: urethrotomy and urethroplasty. At the end of the study, both treatments resulted in similar and better symptom scores. However, the urethroplasty group had fewer reinterventions.

Indexed as

AdultCost-Benefit AnalysisEndoscopyHumansMaleMiddle AgedRecurrenceTreatment OutcomeUrethraUrethral StrictureUrologic Surgical Procedures, MaleRandomised controlled trialSurgeryUrethral strictureUrethroplastyUrethrotomyVoiding symptoms

Identifiers

PMID32636099
OpenAlexW3039145484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.