Evidence map›Paper›PMID 32635769›Full record

ArticleCirculation. Heart failure2020

Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes.

Simone Spinozzi, Canzhao Liu, Ze'e Chen, Wei Feng, Lunfeng Zhang, Kunfu Ouyang, Sylvia M Evans, Ju Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Cardiac Cell Remodeling in Obesity and Diabetes.Handbook of experimental pharmacology · 2026
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  16. Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  17. Article
  18. Understanding the molecular basis of cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Simone Spinozzi *Department of Medicine (S.S., C.L., Z.C., W.F., L.Z., S.M.E., J.C.), University of California San Diego, La Jolla.
Canzhao Liu *Department of Medicine (S.S., C.L., Z.C., W.F., L.Z., S.M.E., J.C.), University of California San Diego, La Jolla.
Ze'e ChenDepartment of Medicine (S.S., C.L., Z.C., W.F., L.Z., S.M.E., J.C.), University of California San Diego, La Jolla.
Wei FengDepartment of Medicine (S.S., C.L., Z.C., W.F., L.Z., S.M.E., J.C.), University of California San Diego, La Jolla.
Lunfeng ZhangDepartment of Medicine (S.S., C.L., Z.C., W.F., L.Z., S.M.E., J.C.), University of California San Diego, La Jolla.
Kunfu OuyangDrug Discovery Center, State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, China (K.O.).
Sylvia M EvansDepartment of Medicine (S.S., C.L., Z.C., W.F., L.Z., S.M.E., J.C.), University of California San Diego, La Jolla.
Ju ChenDepartment of Medicine (S.S., C.L., Z.C., W.F., L.Z., S.M.E., J.C.), University of California San Diego, La Jolla.
University of California San Diego · USPeking University · CN

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Renewing the heart: cardiomyocyte cell cycle regulationR35HL144984 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M · 2019 to 2025
$6.1M
The Cardiac Role of Filamin CR01HL144872 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2019 to 2022
$1.6M
ALPK3 in cardiac function and diseaseR01HL146759 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2019 to 2022
$1.6M
BAG3 in Cardiac function and diseaseR01HL130295 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2016 to 2019
$1.6M
The role of Nexilin in cardiomyocyte and cardiomyopathyR01HL137957 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2017 to 2020
$1.6M
NHLBI NIH HHS R01 HL130295NHLBI NIH HHS R01 HL137957NHLBI NIH HHS R01 HL144872NHLBI NIH HHS R01 HL146759NHLBI NIH HHS R35 HL144984NHLBI NIH HHS T32 HL007444
6 · The paper itself

Abstract

backgroundNEXN (nexilin) is a protein of the junctional membrane complex required for development of cardiac T-tubules. Global and cardiomyocyte-specific loss of

methods

resultsInducible cardiomyocyte-specific loss of

conclusionsResults here reported reveal NEXN to be a pivotal component of adult junctional membrane complexes required for maintenance of transverse-axial tubular architecture. These results demonstrate that NEXN plays an essential role in the adult cardiomyocyte and give further understanding of pathological mechanisms responsible for cardiomyopathy in patients carrying mutations in the NEXN gene.

Indexed as

Age FactorsAnimalsCalciumCardiomyopathy, DilatedDisease Models, AnimalMiceMice, KnockoutMicrofilament ProteinsMicrotubulesMyocytes, CardiacVentricular Dysfunction, LeftCalciumMicrofilament ProteinsNEXN protein, mousedilated cardiomyopathyelectron microscopyheart failuremutationssarcolemma

Identifiers

PMID32635769
PMCPMC7583668
OpenAlexW3041688568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.