ArticleJournal of stroke2020
Outcome of Stroke Patients with Cancer and Nonbacterial Thrombotic Endocarditis.
Article in Journal of stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Stroke secondary to cancer-associated coagulopathy: a systematic review.Journal of neurology · 2026Pooled it
- Acute ischemic stroke, active malignancy and non-bacterial thrombotic endocarditis: an exploratory prospective observational study.Scientific reports · 2026Observational
- Stroke Recurrence and Long-Term Mortality in Patients Diagnosed with Cancer Following Stroke.Yonsei medical journal · 2026Observational
- Mechanism-Oriented Treatment of Early Neurologic Deterioration in Acute Ischemic Stroke.Journal of stroke · 2026Review
- Article
- Article
- Cryptogenic embolic stroke and cancer.Frontiers in neurology · 2025Review
- Predictive nomogram for ischemic stroke risk in clear cell renal cell carcinoma patients.Scientific reports · 2024Article
- Cancer-Associated Stroke: Thrombosis Mechanism, Diagnosis, Outcome, and Therapeutic Strategies.Journal of stroke · 2024Review
- Quadrivalvular nonbacterial thrombotic endocarditis in a patient with clear cell cervical cancer.Clinical case reports · 2022Article
- Different Thrombus Histology in a Cancer Patient with Deep Vein Thrombosis and Recurrent Strokes.Journal of stroke · 2022Article
- Heart-Brain Relationship in Stroke.Biomedicines · 2021Review
- Beyond the coagulopathy phenotype in cancer-associated stroke: routine radiology report-based phenotyping and a practical diagnostic prioritization.Frontiers in neurologyArticle
- Endovascular thrombectomy in selected patients with active cancer and thrombocytopenia: outcomes under an institutional platelet transfusion practice.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeNonbacterial thrombotic endocarditis (NBTE) is a cause of stroke in cancer. However, clinical characteristics and outcomes in stroke patients with cancer-associated NBTE are not well known.
methodsWe included consecutive patients with stroke and active cancer over a 9-year period who underwent echocardiography. We retrospectively compared clinical characteristics and presence of metastasis between patients with NBTE, those with cryptogenic etiologies, and those with determined etiologies. We also investigated mortality and stroke events during the 6-month follow-up.
resultsAmong the 245 patients, 20 had NBTE, 96 had cryptogenic etiologies, and 129 had determined etiologies. Metastasis was seen in all 20 patients (100%) with NBTE, 69.8% in patients with cryptogenic etiology, and 48.8% in patients with or determined etiology. During the 6-month follow-up, 127 patients (51.8%) developed stroke and/or died (death in 110 [44.9%] and stroke events in 55 [22.4%]). Patients with NBTE showed significantly higher mortality (80%) and stroke occurrence (50%) than those with cryptogenic etiologies (mortality 54.2%, stroke 25.0%, log-rank P=0.006) and determined etiologies (mortality 32.6%, stroke 16.3%, log-rank P<0.001). In a multivariate Cox proportional hazard analysis, the presence of NBTE was independently associated with composite outcomes of mortality and stroke events (hazard ratio, 1.941; 95% confidence interval, 1.052 to 3.690).
conclusionsNBTE should be suspected as a potential cause of stroke in patients with metastatic cancer. Patients with NBTE have a high risk of recurrent stroke and mortality. Future studies are necessary to determine strategies to reduce stroke recurrence in patients with NBTE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.