Evidence map›Paper›PMID 32635530›Full record

ArticleMolecules (Basel, Switzerland)2020

Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation.

Buthina A Al-Oudat, Hariteja Ramapuram, Saloni Malla, Suaad A Audat, Noor Hussein, Jenna M Len, Shikha Kumari, Mel F Bedi, Charles R Ashby, Amit K Tiwari

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Synthesis,Journal of enzyme inhibition and medicinal chemistry · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Anticancer Activity of Ether Derivatives of Chrysin.Molecules (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Article
  9. Antiproliferative Efficacy ofMolecules (Basel, Switzerland) · 2021
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Buthina A Al-OudatDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Hariteja RamapuramDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Saloni MallaDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Suaad A AudatDepartment of Chemistry, College of Science and Arts, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.ORCID 0000-0003-4486-4962
Noor HusseinDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Jenna M LenDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Shikha KumariDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Mel F BediDepartment of Medicinal and Biological Chemistry, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-4976-5157
Charles R AshbyDepartment of Pharmaceutical Sciences, College of Pharmacy & Pharmaceutical Sciences, St. John's University, Queens, NY 11439, USA.
Amit K TiwariDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-7427-7155

Funding

Jordan University of Science and Technology 360/2019Susan G. Komen CCR18548498University of Toledo F110760
6 · The paper itself

Abstract

New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (

Indexed as

Allyl CompoundsAntineoplastic AgentsApoptosisCell CycleCell MovementCell ProliferationFemaleFlavonoidsHumansHydrazonesPiperazinesTriple Negative Breast NeoplasmsTumor Cells, Cultured(4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazineAllyl CompoundsAntineoplastic AgentschrysinFlavonoidsHydrazonesPiperazinesanticancer compoundschrysin analoguescytotoxicityflavonoidtriple-negative breast cancer

Identifiers

PMID32635530
PMCPMC7412250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.