Evidence map›Paper›PMID 32635479›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis and Antimicrobial Activity of Novel 4-Hydroxy-2-quinolone Analogs.

Thitiphong Khamkhenshorngphanuch, Kittipat Kulkraisri, Alongkorn Janjamratsaeng, Napasawan Plabutong, Arsa Thammahong, Kanitta Manadee, Sarisa Na Pombejra, Tanatorn Khotavivattana

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Molecules (Basel, Switzerland) · 2024
    Article
  5. BiClRSC advances · 2023
    Article
  6. Structural modification of theMicrobiology (Reading, England) · 2023
    Article
  7. Autoxidation of 4-Hydrazinylquinolin-2(1Molecules (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thitiphong KhamkhenshorngphanuchDepartment of General Education, Faculty of Science and Health Technology, Navamindradhiraj University, Bangkok 10300, Thailand.
Kittipat KulkraisriDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Alongkorn JanjamratsaengDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Napasawan PlabutongAntimicrobial Resistance and Stewardship Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Arsa ThammahongAntimicrobial Resistance and Stewardship Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-0482-4176
Kanitta ManadeeDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Sarisa Na PombejraDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Tanatorn KhotavivattanaCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-7236-0625

Funding

Chulalongkorn University DNS62_081_23_014_2Higher Education Commission, Thailand MRG6280024Thailand Research Fund MRG6280024
6 · The paper itself

Abstract

Alkyl quinolone has been proven to be a privileged scaffold in the antimicrobial drug discovery pipeline. In this study, a series of new 4-hydroxy-2-quinolinone analogs containing a long alkyl side chain at C-3 and a broad range of substituents on the C-6 and C-7 positions were synthesized. The antibacterial and antifungal activities of these analogs against

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBacteriaFungiMolecular StructureQuinolonesAnti-Bacterial AgentsAntifungal AgentsQuinolones4-hydroxy-2-quinolinoneantibacterialantifungalstructure–activity relationship

Identifiers

PMID32635479
PMCPMC7412474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.