Evidence map›Paper›PMID 32635475›Full record

ArticleViruses2020

STAT2 Limits Host Species Specificity of Human Metapneumovirus.

Meredith C Rogers, Margot Miranda-Katz, Yu Zhang, Tim D Oury, Melissa B Uccellini, Adolfo García-Sastre, John V Williams

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Meredith C RogersDepartment of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.ORCID 0000-0003-1798-6294
Margot Miranda-KatzDepartment of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Yu ZhangDepartment of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Tim D OuryDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Melissa B UccelliniDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-6551-1827
John V WilliamsDepartment of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
University of Pittsburgh · USIcahn School of Medicine at Mount Sinai · USTisch Hospital · US

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Autoimmunity and Immunopathology Training ProgramT32AI089443 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2010 to 2024
$6.6M
Host Determinants of Human Metapneumovirus Immunity and PathogenesisR01AI085062 · NIAID · VANDERBILT UNIVERSITY · PI John V. Williams · 2010 to 2026
$5.6M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
NCI NIH HHS P30 CA196521NIAID NIH HHS R01 AI085062NIAID NIH HHS T32 AI089443NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284
6 · The paper itself

Abstract

The host tropism of viral infection is determined by a variety of factors, from cell surface receptors to innate immune signaling. Many viruses encode proteins that interfere with host innate immune recognition in order to promote infection. STAT2 is divergent between species and therefore has a role in species restriction of some viruses. To understand the role of STAT2 in human metapneumovirus (HMPV) infection of human and murine tissues, we first infected STAT2

Indexed as

AnimalsFemaleHost SpecificityHumansImmunity, InnateInterferonsMaleMetapneumovirusMiceMice, Inbred C57BLMice, KnockoutParamyxoviridae InfectionsSTAT2 Transcription FactorTh2 CellsInterferonsSTAT2 protein, humanStat2 protein, mouseSTAT2 Transcription Factoracute respiratory infectionhuman metapneumovirusinnate immunitySTAT1STAT2type I interferonvirus tropism

Identifiers

PMID32635475
PMCPMC7412095
OpenAlexW3038943325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.