Evidence map›Paper›PMID 32635406›Full record

ArticleMetabolites2020

Modulation of Phenylalanine and Tyrosine Metabolism in HIV-1 Infected Patients with Neurocognitive Impairment: Results from a Clinical Trial.

Giuseppe P Innocenti, Letizia Santinelli, Luca Laghi, Cristian Borrazzo, Claudia Pinacchio, Mariangela Fratino, Luigi Celani, Eugenio N Cavallari, Carolina Scagnolari, Federica Frasca and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Giuseppe P InnocentiDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.
Letizia SantinelliDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0002-5621-058X
Luca LaghiDepartment of Agro-Food Science and Technology, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy.ORCID 0000-0003-1593-7376
Cristian BorrazzoDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0002-2346-898X
Claudia PinacchioDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.
Mariangela FratinoDepartment of Neurology Sapienza, University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Luigi CelaniDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.
Eugenio N CavallariDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0002-6021-484X
Carolina ScagnolariLaboratory of Virology, Department of Molecular Medicine, Affiliated to Istituto Pasteur Italia-Cenci Bolognetti Foundation, Sapienza, University of Rome, 00185 Rome, Italy.
Federica FrascaLaboratory of Virology, Department of Molecular Medicine, Affiliated to Istituto Pasteur Italia-Cenci Bolognetti Foundation, Sapienza, University of Rome, 00185 Rome, Italy.
Guido AntonelliLaboratory of Virology, Department of Molecular Medicine, Affiliated to Istituto Pasteur Italia-Cenci Bolognetti Foundation, Sapienza, University of Rome, 00185 Rome, Italy.
Claudio M MastroianniDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0002-1286-467X
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0002-3571-5677
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, Sapienza, University of Rome, viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0001-5921-3180
Policlinico Umberto I · ITIstituto Pasteur · ITSapienza University of Rome · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the effects of oral bacteriotherapy on intestinal phenylalanine and tyrosine metabolism, in this longitudinal, double-arm trial, 15 virally suppressed HIV+ individuals underwent blood and fecal sample collection at baseline and after 6 months of oral bacteriotherapy. A baseline fecal sample was collected from 15 healthy individuals and served as control group for the baseline levels of fecal phenylalanine and tyrosine. CD4 and CD8 immune activation (CD38

Indexed as

HIVinflammationmetabolismneurocognitive impairmentphenylalanineprobioticstyrosine

Identifiers

PMID32635406
PMCPMC7408387
OpenAlexW3038678598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.