Evidence map›Paper›PMID 32635347›Full record

ArticleInternational journal of molecular sciences2020

The Fungal Iron Chelator Desferricoprogen Inhibits Atherosclerotic Plaque Formation.

László Potor, Sikura Katalin Éva, Hajnalka Hegedűs, Dávid Pethő, Zsuzsa Szabó, Zsuzsa M Szigeti, István Pócsi, György Trencsényi, Dezső Szikra, Ildikó Garai and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Ferroptosis as a target mechanism in heart and kidney disease.The Journal of clinical investigation · 2026
    Review
  2. Review
  3. Review
  4. Effect of autophagy on ferroptosis in foam cells via Nrf2.Molecular and cellular biochemistry · 2022
    Article
  5. Article
  6. Review
  7. Iron in Cardiovascular Disease: Challenges and Potentials.Frontiers in cardiovascular medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

László PotorHAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, University of Debrecen, 4012 Debrecen, Hungary.
Sikura Katalin ÉvaHAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, University of Debrecen, 4012 Debrecen, Hungary.ORCID 0000-0002-7280-1865
Hajnalka HegedűsDivision of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen,4012 Debrecen, Hungary.
Dávid PethőDivision of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen,4012 Debrecen, Hungary.ORCID 0000-0001-7549-5691
Zsuzsa SzabóDepartment of Molecular Biotechnology and Microbiology, Institute of Technology, Faculty of Science and Technology, University of Debrecen, 4012 Debrecen, Hungary.
Zsuzsa M SzigetiDepartment of Molecular Biotechnology and Microbiology, Institute of Technology, Faculty of Science and Technology, University of Debrecen, 4012 Debrecen, Hungary.
István PócsiDepartment of Molecular Biotechnology and Microbiology, Institute of Technology, Faculty of Science and Technology, University of Debrecen, 4012 Debrecen, Hungary.
György TrencsényiScanomed Ltd., University of Debrecen, 4012 Debrecen, Hungary.
Dezső SzikraScanomed Ltd., University of Debrecen, 4012 Debrecen, Hungary.
Ildikó GaraiScanomed Ltd., University of Debrecen, 4012 Debrecen, Hungary.
Tamás GállHAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, University of Debrecen, 4012 Debrecen, Hungary.
Zsolt CombiDivision of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen,4012 Debrecen, Hungary.
János KappelmayerDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.
György BallaHAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, University of Debrecen, 4012 Debrecen, Hungary.
József BallaHAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, University of Debrecen, 4012 Debrecen, Hungary.
University of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemoglobin, heme and iron are implicated in the progression of atherosclerosis. Therefore, we investigated whether the hydrophobic fungal iron chelator siderophore, desferricoprogen (DFC) inhibits atherosclerosis. DFC reduced atherosclerotic plaque formation in ApoE

Indexed as

AnimalsAortaAtherosclerosisDiet, AtherogenicDiketopiperazinesDisease Models, AnimalDisease ProgressionFoam CellsHemeHydroxamic AcidsLipid PeroxidationLipoproteins, LDLMacrophage ActivationMagnetic Resonance ImagingMiceMice, Inbred C57BLdesferricoprogenDiketopiperazinesHemeHydroxamic AcidsLipoproteins, LDLSiderophoresapolipoprotein e knockout mouseatherosclerosisinflammationlipid peroxidationpositron emission tomographysiderophore

Identifiers

PMID32635347
PMCPMC7369830
OpenAlexW3039876339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.