Evidence map›Paper›PMID 32635160›Full record

ArticleAntibodies (Basel, Switzerland)2020

CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in

Tapan K Biswas, Paul A VanderLaan, Xuchu Que, Ayelet Gonen, Paulette Krishack, Christoph J Binder, Joseph L Witztum, Godfrey S Getz, Catherine A Reardon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibodies (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tapan K BiswasDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Paul A VanderLaanDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-7234-5652
Xuchu QueDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6751-5493
Ayelet GonenDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Paulette KrishackDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Christoph J BinderDepartment of Laboratory Medicine, Medical University of Vienna, Vienna 1090, Austria.
Joseph L WitztumDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5195-6614
Godfrey S GetzDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Catherine A ReardonDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-3101-9612
University of Chicago · USUniversity of California San Diego · USBeth Israel Deaconess Medical Center · USMedical University of Vienna · AT

Funding

Fondation Leducq Immune Modulation of Cardiovascular DiseaseNIH HHS HL88420, HL86559, HL88093
6 · The paper itself

Abstract

Natural antibodies (NAbs) are important regulators of tissue homeostasis and inflammation and are thought to have diverse protective roles in a variety of pathological states. E06 is a T15 idiotype IgM NAb exclusively produced by B-1 cells, which recognizes the phosphocholine (PC) head group in oxidized phospholipids on the surface of apoptotic cells and in oxidized LDL (OxLDL), and the PC present on the cell wall of

Indexed as

CD1dinnate immunitynatural antibodiesoxidized lipids

Identifiers

PMID32635160
PMCPMC7551411
OpenAlexW3039589699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.