Evidence map›Paper›PMID 32634589›Full record

SynthesisInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2020

A potentially effective treatment for COVID-19: A systematic review and meta-analysis of convalescent plasma therapy in treating severe infectious disease.

Mengyao Sun, Yinghui Xu, Hua He, Li Zhang, Xu Wang, Qing Qiu, Chao Sun, Ye Guo, Shi Qiu, Kewei Ma

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05046652 (Effectiveness of Convalescent Plasma Therapy in 8 Non-Intubated COVID-19 Patients in Indonesia), which is not on this map. Cited by 39 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 6 pooled it
1.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05046652 completednot on this map

Effectiveness of Convalescent Plasma Therapy in 8 Non-Intubated COVID-19 Patients in Indonesia: A Case Series

TypeobservationalSponsorMaranatha Christian UniversityRan2020 to 2020Enrolled8ConditionsInfectious DiseaseArmsConvalescent Plasma Therapy
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. SARS-CoV-2 serology and virology trends in donors and recipients of convalescent plasma.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2020
    Trial
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mengyao SunCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Yinghui XuCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Hua HeCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Li ZhangRadiology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Xu WangCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Qing QiuAcademy of Life Sciences, Northeast Normal University, Changchun, Jilin 130024, China.
Chao SunCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Ye GuoCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Shi QiuCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Kewei MaCancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China. Electronic address: makw@jlu.edu.cn.
Jilin University · CNNortheast Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConvalescent plasma (CP) has been used successfully to treat many types of infectious disease, and has shown initial effects in the treatment of the emerging 2019 coronavirus disease (COVID-19). However, its curative effects and feasibility have yet to be confirmed by formal evaluation and well-designed clinical trials. To explore the effectiveness of treatment and predict the potential effects of CP with COVID-19, studies of different types of infectious disease treated with CP were included in this systematic review and meta-analysis.

methodsRelated studies were obtained from databases and screened according to the inclusion criteria. The data quality was assessed, and the data were extracted and pooled for analysis.

results40 studies on CP treatment for infectious diseases were included. Our study found that CP treatment could reduce the risk of mortality, with a low incidence of adverse events, promote the production of antibodies, lead to a decline in viral load, and shorten the disease course. A meta-analysis of 15 controlled studies showed that there was a significantly lower mortality rate in the group treated with CP (pooled OR=0.32; 95% CI=0.19-0.52; p<0.001, I

conclusionsCP therapy has some curative effect and is well tolerated in treating infectious diseases. It is a potentially effective treatment for COVID-19.

Indexed as

Antibodies, ViralBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 SerotherapyHumansImmunization, PassivePandemicsPlasmaPneumonia, ViralSARS-CoV-2Treatment OutcomeViral LoadAntibodies, ViralConvalescent plasma (CP)Coronavirus disease 2019 (COVID-19)Infectious diseaseMeta-analysis

Identifiers

PMID32634589
PMCPMC7334933
OpenAlexW3040406962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.