Evidence map›Paper›PMID 32634189›Full record

ArticleCell medicine2018

A Comparison of Pancreatic Islet Purification using Iodixanol with University of Wisconsin Solution and with Na-Lactobionate and Histidine Solution.

Yoshiki Nakashima, Chika Miyagi-Shiohira, Nana Ebi, Eri Hamada, Yoshihito Tamaki, Kazuho Kuwae, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Takao Kinjo and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Cell medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yoshiki NakashimaDepartment of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Chika Miyagi-ShiohiraDepartment of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Nana EbiDepartment of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Eri HamadaDepartment of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Yoshihito TamakiDepartment of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Kazuho KuwaeDepartment of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Naoya KobayashiOkayama Saidaiji Hospital, Okayama Prefecture, Japan.
Issei SaitohDivision of Pediatric Dentistry, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.
Masami WatanabeDepartment of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Prefecture, Japan.
Takao KinjoDivision of Morphological Pathology, Department of Basic Laboratory Sciences, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Hirofumi NoguchiDepartment of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa Prefecture, Japan.
Okinawa Prefecture · JPUniversity of the Ryukyus · JPOkayama Prefecture · JPNiigata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purification of pancreatic islets is an important step in islet isolation for islet transplantation. In this study, to investigate how a solution composed mainly of Na-lactobionate and histidine (HL) influences the purification of islets, iodixanol was added to a purified solution for porcine islet isolation. A solution (IU) made by adding iodixanol to University of Wisconsin solution and a solution (IHL) made by adding iodixanol to HL solution were used to evaluate the islet isolation performance. We noted no significant differences between the two purification methods with regard to the islet yield, survival rate or purity, score, or stimulation index. These results show that IHL solution is as useful as IU solution for islet purification.

Indexed as

bottle purificationcontinuous density gradientislet isolationislet purificationIslet transplantation

Identifiers

PMID32634189
PMCPMC6172993
OpenAlexW2807324565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.