ArticleAfrican journal of primary health care & family medicine2020
Sensitivity and specificity of malaria rapid diagnostic test (mRDT CareStatTM) compared with microscopy amongst under five children attending a primary care clinic in southern Nigeria.
Article in African journal of primary health care & family medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Performance of rapid diagnostic tests for malaria diagnosis in Nigeria: a systematic review and meta-analysis.Malaria journal · 2025Pooled it
- Evaluation of malaria rapid diagnostic test kit performance in a high-transmission setting: a facility-based cross-sectional study in rural Ghana.Malaria journal · 2026Article
- Advancements and Applications of Lateral Flow Assays (LFAs): A Comprehensive Review.Sensors (Basel, Switzerland) · 2025Review
- Article
- Identification of visible and near-infrared signature peaks for arboviruses and Plasmodium falciparum.PloS one · 2025Article
- Point-of-Care Evaluation of Malaria Rapid Diagnostic Test (mRDT) for Detection ofJournal of parasitology research · 2025Article
- Diagnostic accuracy ofExperimental biology and medicine (Maywood, N.J.) · 2025Article
- Comparative evaluation of the diagnostic accuracies of four different malaria rapid diagnostic test kits available in Ghana.PloS one · 2024Article
- Development of a low-cost robotized 3D-prototype for automated optical microscopy diagnosis: An open-source system.PloS one · 2024Article
- Key considerations, target product profiles, and research gaps in the application of infrared spectroscopy and artificial intelligence for malaria surveillance and diagnosis.Malaria journal · 2023Review
- Implementation of the Revised National Malaria Control Guidelines: Compliance and Challenges in Public Health Facilities in a Southern Nigerian State.Health services insights · 2023Article
- Performance Evaluation of Nested Polymerase Chain Reaction (Nested PCR), Light Microscopy, andPathogens (Basel, Switzerland) · 2022Article
- Malaria rapid diagnostic tests for the case management of febrile children in Nigerian primary healthcare settings: a cross-sectional study.The Journal of the Egyptian Public Health Association · 2022Article
- Field Evaluation of a Hemozoin-Based Malaria Diagnostic Device in Puerto Lempira, Honduras.Diagnostics (Basel, Switzerland) · 2022Article
- Assessing Asymptomatic Malaria Carriage ofChildren (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria diagnosis using microscopy is currently the gold standard. However, malaria rapid diagnostic tests (mRDTs) were developed to simplify the diagnosis in regions without access to functional microscopy.
aimThe objective of this study was to compare the diagnostic accuracy of mRDT CareStatTM with microscopy.
settingThis study was conducted in the paediatric primary care clinic of the Federal Medical Centre, Asaba, Nigeria.
methodsA cross-sectional study for diagnostic accuracy was conducted from May 2016 to October 2016. Ninety-eight participants were involved to obtain a precision of 5%, sensitivity of mRDT CareStatTM of 95% from published work and 95% level of confidence after adjusting for 20% non-response rate or missing data. Consecutive participants were tested using both microscopy and mRDT. The results were analysed using EPI Info Version 7.
resultsA total of 98 children aged 3-59 months were enrolled. Malaria prevalence was found to be 53% (95% confidence interval [CI] = 46% - 60%), whilst sensitivity and specificity were 29% (95% CI = 20% - 38%) and 89% (95% CI = 83% - 95%), respectively. The positive and negative predictive values were 75% (95% CI = 66.4% - 83.6%) and 53% (95% CI = 46% - 60%), respectively.
conclusionAgreement between malaria parasitaemia using microscopy and mRDT positivity increased with increase in the parasite density. The mRDT might be negative when malaria parasite density using microscopy is low.
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