ArticleThe journal of physical chemistry. B2020
Application of Graphene as a Nanoindenter Interacting with Phospholipid Membranes-Computer Simulation Study.
Article in The journal of physical chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Exploring 2D Graphene-Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective.Small science · 2025Article
- Steered Molecular Dynamics of Lipid Membrane Indentation by Carbon and Silicon-Carbide Nanotubes-The Impact of Indenting Angle Uncertainty.Sensors (Basel, Switzerland) · 2021Article
- Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Article
- Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery.Frontiers in molecular biosciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthesis of graphene (GN) in 2004 stimulated wide interest in potential applications of 2D materials in catalysis, optoelectronics, biotechnology, and construction of sensing devices. In the presented study, interactions between GN sheets and phospholipid bilayers are examined using steered molecular dynamics simulations. GN sheets of different sizes were inserted into a bilayer and subsequently withdrawn from it at two different rates (1 and 2 m/s). In some cases, nanoindentation led to substantial damage of the phospholipid bilayer; however, an effective self-sealing process occurred even after significant degradation. The average force and work, deflection of the membrane during indentation, withdrawal processes, and structural changes caused by moving sheets are discussed. These quantities are utilized to estimate the suitability of GN sheets for targeted drug delivery or other nanomedicine tools. The results are compared with those obtained for other nanostructures such as homogeneous and heterogeneous nanotubes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.