Evidence map›Paper›PMID 32633896›Full record

Trial reportInternational wound journal2020

The effect of transcutaneous application of gaseous CO

Milos Macura, Helena Ban Frangez, Ksenija Cankar, Miha Finžgar, Igor Frangez

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International wound journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04561609 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Transcutaneous Application of Gaseous CO2 on Diabetic Chronic Wound Healing

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2023 to 2025Enrolled120ConditionsChronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)ArmsTranscutaneous CO2 application
NCT07418073 nacompletednot on this mapstarted 2024, after this paper: background citation

Transcutaneous CO₂ Therapy in Recurrent Hard-to-Heal Diabetic Foot Ulcers

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2024 to 2025Enrolled30ConditionsUlcer FootArmstranscutaneous application of gaseous CO2 on lower part of the body
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Synergistic COInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Topical Carboxytherapy for Skin Rejuvenation.The Journal of clinical and aesthetic dermatology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Milos MacuraDepartment for surgical infections, University Medical center Ljubljana, Ljubljana, Slovenia.
Helena Ban FrangezDepartment of Obstetrics and Gynaecology, University Medical center Ljubljana, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0002-2652-6671
Ksenija CankarInstitute of Physiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Miha FinžgarFaculty of Mechanical Engineering, University of Ljubljana, Ljubljana, Slovenia.
Igor FrangezDepartment for surgical infections, University Medical center Ljubljana, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-9963-8810

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds in diabetics are difficult to treat, therefore, adjuvant therapies have been investigated. Bathing in CO

Indexed as

Diabetes MellitusDiabetic FootWound HealingAgedCarbon DioxideDouble-Blind MethodEuropeFemaleHumansMaleMiddle AgedCarbon Dioxidecarboxy therapychronic wound treatmentCO2 therapydiabetic chronic wounddiabetic foot ulcertranscutaneous CO2 application

Identifiers

PMID32633896
PMCPMC7949258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.