Evidence map›Paper›PMID 32633836›Full record

ArticleJournal of the American Geriatrics Society2020

Application of Cut-Points for Low Muscle Strength and Lean Mass in Mobility-Limited Older Adults.

Gregory J Grosicki, Thomas G Travison, Hao Zhu, Jay Magaziner, Ellen F Binder, Marco Pahor, Rosaly Correa-de-Araujo, Peggy M Cawthon, Shalender Bhasin, Denise Orwig and 6 more

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
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  10. Associations of components of sarcopenia with risk of fracture in the Osteoporotic Fractures in Men (MrOS) study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
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  17. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Gregory J GrosickiNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts.ORCID 0000-0001-8929-4903
Thomas G TravisonBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Hao ZhuMarcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
Jay MagazinerSchool of Medicine, University of Maryland, Baltimore, Maryland.
Ellen F BinderDivision of Geriatrics & Nutritional Science, Washington University School of Medicine, St. Louis, Missouri.
Marco PahorDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida.
Rosaly Correa-de-AraujoU.S. Department of Health and Human Services, Division of Geriatrics and Clinical Gerontology, National Institute of Aging, National Institutes of Health, Bethesda, Maryland.
Peggy M CawthonSan Francisco Coordinating Center, California Pacific Medical Research Institute, San Francisco, California.ORCID 0000-0003-4938-9478
Shalender BhasinResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, Boston, Massachusetts.
Denise OrwigSchool of Medicine, University of Maryland, Baltimore, Maryland.
Susan GreenspanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Todd ManiniDepartment of Aging and Geriatric Research, University of Florida, Gainesville, Florida.
Joe MassaroDepartment of Biostatistics, Harvard Clinical Research Institute, Boston, Massachusetts.
Adam SantanastoDepartment of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Sheena PatelDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California.
Roger A FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SHALENDER BHASIN · 2008 to 2026
$23.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Muscle Mass and Strength Cutpoints in Persons at Risk of Mobility Disability-A1U01AG051421 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER, CAWTHON, PEGGY MANNEN · 2015 to 2017
$1.7M
Training in Molecular Epidemiology: Linking Genes to Physical Function in Older AdultsK01AG057726 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANTANASTO, ADAM J · 2018 to 2022
$582k
Position Development Conference for Sarcopenia Definitions and OutcomesR13AG060712 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER, CAWTHON, PEGGY MANNEN · 2018 to 2018
$50k
NIA NIH HHS 1R13AG060712-01NIA NIH HHS 1U01AG051421NIA NIH HHS K01 AG057726NIA NIH HHS P30 AG021332NIA NIH HHS P30AG021332NIA NIH HHS P30 AG024827NIA NIH HHS P30AG024827NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG028747NIA NIH HHS P30 AG031679NIA NIH HHS R13 AG060712NIA NIH HHS U01 AG051421NIDDK NIH HHS P30 DK056341NIH HHS 1P30AG031679NIH HHS 1U01AG051421NIH HHS AGR0112257NIH HHS AGR0118915NIH HHS and P30AG024827NIH HHS P30AG021332
6 · The paper itself

Abstract

backgroundThe Sarcopenia Definitions and Outcomes Consortium (SDOC) is a collaborative initiative seeking to develop and evaluate cut-points for low muscle strength and lean mass that predict an increased risk for slowness (usual walking speed <.8 m/s) among older adults.

objectivesThe goal of the present study was to provide clinicians and researchers with an understanding of the diagnostic implications of using SDOC variables and cut-points in mobility-limited older adults. Using data from older individuals with specific conditions that render them at increased risk for mobility limitation, we evaluated the performance characteristics (ie, sensitivity and specificity) of five putative sarcopenia parameters and then compared these values with previously recommended diagnostic criteria for sarcopenia.

designRetrospective analysis of six randomized controlled trials enriched in persons at risk for mobility limitation.

settingNational and international geriatric clinical research centers.

participantsA total of 925 mobility-limited older adults (≥55 years of age; 58% women) were included in the analysis. MEASUREMENTS: The prevalence of low muscle strength and lean mass were assessed using five candidate metrics discriminative of slowness. Analyses of sensitivity and specificity were used to compare muscle weakness criteria with published diagnostics for sarcopenia.

resultsOdds ratios (ORs) supported maximal grip strength (Grip max <35.5 and 20.0 in men and women, respectively) as the most discriminative of slowness in both men and women (OR = 3.66 and 3.53, respectively). More men (58%) than women (30%) fell below sex-specific maximal grip cut-points. When applying previously recommended sarcopenia component definitions in our population, we found that fewer individuals met those criteria (range = 6%-32%).

conclusionA greater number of individuals fall below SDOC Grip max cut-points compared with previous recommendations. Clinicians and researchers working with older adults may consider these thresholds as an inclusive means to identify candidates for low-risk lifestyle promyogenic and function-promoting therapies. J Am Geriatr Soc 68:1445-1453, 2020.

Indexed as

AgingMuscle WeaknessSarcopeniaAgedAged, 80 and overFemaleGeriatric AssessmentHand StrengthHumansIndependent LivingMaleMobility LimitationMuscle StrengthPrevalenceRandomized Controlled Trials as TopicWalking Speedagingmusclephysical functionsarcopenia

Identifiers

PMID32633836
PMCPMC7440655

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.