Evidence map›Paper›PMID 32633719›Full record

ArticleeLife2020

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

Walter R Mancia Leon, Julien Spatazza, Benjamin Rakela, Ankita Chatterjee, Viraj Pande, Tom Maniatis, Andrea R Hasenstaub, Michael P Stryker, Arturo Alvarez-Buylla

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  8. Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  9. Article
  10. Interneuron Diversity: How Form Becomes Function.Cold Spring Harbor perspectives in biology · 2025
    Review
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  14. Synaptic gene expression changes in frontotemporal dementia due to themedRxiv : the preprint server for health sciences · 2024
    Article
  15. Article
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  18. The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Walter R Mancia Leon *Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-1920-6514
Julien Spatazza *Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
Benjamin RakelaDepartment of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States.
Ankita ChatterjeeDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
Viraj PandeDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.
Tom ManiatisDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Andrea R HasenstaubDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-3998-5073
Michael P StrykerDepartment of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, United States.
Arturo Alvarez-BuyllaDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-4426-8925
University of California, San Francisco · USColumbia University · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAKKARAJU, APARNA · 1985 to 2024
$16.8M
NEUROGENESIS IN THE ADULT VERTEBRATE BRAINR01NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1996 to 2024
$8.6M
DEVELOPMENT &PLASTICITY OF THE VISUAL SYSTEMR01EY002874 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STRYKER, MICHAEL P · 1986 to 2022
$6.4M
Interneuron Precursors and the induction of cortical plasticityR01EY025174 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO, HASENSTAUB, ANDREA RAYNE · 2015 to 2019
$2.1M
Dynamic regulation of auditory context processing by cortical inhibitionR01DC014101 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HASENSTAUB, ANDREA RAYNE · 2014 to 2018
$1.9M
Functional Integration of Medial Ganglionic Eminence Interneuron Transplants into Visual CortexF32EY029935 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RAKELA, BENJAMIN · 2019 to 2021
$196k
NEI NIH HHS F32 EY029935NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY002874NEI NIH HHS R01 EY025174NIDCD NIH HHS R01 DC014101NIH HHS EY02517NINDS NIH HHS R01 NS028478
6 · The paper itself

Abstract

Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their numbers are adjusted by programmed cell death. Here, we show that loss of clustered gamma protocadherins (

Indexed as

ApoptosisAnimalsCadherin Related ProteinsCadherinsCerebral CortexFemaleInterneuronsMaleMiceCadherin Related ProteinsCadherinsGamma-protocadherinsdevelopmental biologyMGEmouseneuroscienceprogrammed cell deathprotocadherinstransplantation

Identifiers

PMID32633719
PMCPMC7373431
OpenAlexW3041415249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.