Evidence map›Paper›PMID 32633672›Full record

ArticleEpigenetics2021

DNA methylation and hydroxymethylation have distinct genome-wide profiles related to axonal regeneration.

Andy Madrid, Laura E Borth, Kirk J Hogan, Nithya Hariharan, Ligia A Papale, Reid S Alisch, Bermans J Iskandar

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Role of Methylation Modification in Neural Injury and Repair.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Evaluation of photobiomodulation therapy (117 and 90s) on pain, regeneration, and epigenetic factors (HDAC 2, DNMT3a) expression following spinal cord injury in a rat model.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andy MadridDepartment of Neurological Surgery, University of Wisconsin - Madison , Madison, WI, USA.
Laura E BorthDepartment of Neurological Surgery, University of Wisconsin - Madison , Madison, WI, USA.ORCID 0000-0002-2487-5341
Kirk J HoganDepartment of Anesthesiology, University of Wisconsin - Madison , Madison, WI, USA.ORCID 0000-0001-6329-2651
Nithya HariharanDepartment of Neurological Surgery, University of Wisconsin - Madison , Madison, WI, USA.
Ligia A PapaleDepartment of Neurological Surgery, University of Wisconsin - Madison , Madison, WI, USA.
Reid S AlischDepartment of Neurological Surgery, University of Wisconsin - Madison , Madison, WI, USA.ORCID 0000-0003-0637-4137
Bermans J IskandarDepartment of Neurological Surgery, University of Wisconsin - Madison , Madison, WI, USA.
University of Wisconsin–Madison · US

Funding

Folic Acid Enhances Repair Mechanism in the Adult CNSR01HD047516 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ISKANDAR, BERMANS J · 2006 to 2010
$964k
Defining the Molecular Origins of Developmental Brain DisordersF31MH113351 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI MADRID, ANDY · 2017 to 2019
$98k
HSRD VA IIR 14-435NICHD NIH HHS R01 HD047516NIMH NIH HHS F31 MH113351
6 · The paper itself

Abstract

Alterations in environmentally sensitive epigenetic mechanisms (

Indexed as

DNA Methylation5-MethylcytosineAnimalsAxonsEpigenesis, GeneticFemaleMaleNerve RegenerationRatsRats, Sprague-DawleyTranscriptome5-hydroxymethylcytosine5-Methylcytosineaxonal regenerationDNA methylationepigeneticsFolatetranscriptometransgenerational

Identifiers

PMID32633672
PMCPMC7889172
OpenAlexW3040338560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.