Evidence map›Paper›PMID 32633531›Full record

ArticleInorganic chemistry2020

Exploring the In Vivo and In Vitro Anticancer Activity of Rhenium Isonitrile Complexes.

Sierra C Marker, A Paden King, Samantha Granja, Brett Vaughn, Joshua J Woods, Eszter Boros, Justin J Wilson

Open access · greenAbstract read
In one paragraph

Article in Inorganic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Early Transition Metal-Based Antitumor Complexes.Chemistry, an Asian journal · 2026
    Review
  4. Synthesis of aACS omega · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Exploring the in vitro anticancer activities of Re(I) picolinic acid and its fluorinated complex derivatives on lung cancer cells: a structural study.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. ReAngewandte Chemie (International ed. in English) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sierra C MarkerDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
A Paden KingDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Samantha GranjaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Brett VaughnDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Joshua J WoodsDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID http://orcid.org/0000-0002-6213-4093
Eszter BorosDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.ORCID http://orcid.org/0000-0002-4186-6586
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID http://orcid.org/0000-0002-4086-7982
Cornell University · USStony Brook University · US

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
NIGMS NIH HHS T32 GM008500
6 · The paper itself

Abstract

The established platinum-based drugs form covalent DNA adducts to elicit their cytotoxic response. Although they are widely employed, these agents cause toxic side-effects and are susceptible to cancer-resistance mechanisms. To overcome these limitations, alternative metal complexes containing the rhenium(I) tricarbonyl core have been explored as anticancer agents. Based on a previous study (

Indexed as

AnimalsAntineoplastic AgentsCoordination ComplexesEndoplasmic Reticulum StressFemaleHeLa CellsHumansLigandsLuminescent AgentsMice, Inbred BALB CNitrilesRheniumSmall Molecule LibrariesUnfolded Protein ResponseXenograft Model Antitumor AssaysAntineoplastic AgentsCoordination ComplexesLigandsLuminescent AgentsNitrilesRheniumSmall Molecule Libraries

Identifiers

PMID32633531
PMCPMC8114230
OpenAlexW3038588633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.