Evidence map›Paper›PMID 32633472›Full record

ArticleAndrology2020

Borderline-low testosterone levels are associated with lower left ventricular wall thickness in firefighters: An exploratory analysis.

Adriana Lofrano-Porto, Edgard M K V K Soares, Alexs Matias, Luiz Guilherme Grossi Porto, Denise L Smith

Open access · hybridAbstract read
In one paragraph

Article in Andrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Adriana Lofrano-PortoAdrenal and Gonadal Diseases Clinic, Section of Endocrinology and Metabolism of the University Hospital, Molecular Pharmacology Laboratory, Graduate Program in Health Sciences, University of Brasilia - UnB, Brasilia, Brazil.ORCID 0000-0002-9590-1631
Edgard M K V K SoaresFaculty of Physical Education, Exercise Physiology Laboratory, Study Group on Exercise and Physical Activity Physiology and Epidemiology, University of Brasilia - UnB, Brasilia, Brazil.ORCID 0000-0002-3696-9556
Alexs MatiasDepartment of Health and Human Physiological Sciences, Skidmore College, First Responder Health and Safety Laboratory, Saratoga Springs, NY, USA.ORCID 0000-0003-2318-524X
Luiz Guilherme Grossi PortoFaculty of Physical Education, Exercise Physiology Laboratory, Study Group on Exercise and Physical Activity Physiology and Epidemiology, University of Brasilia - UnB, Brasilia, Brazil.ORCID 0000-0002-6240-1614
Denise L SmithDepartment of Health and Human Physiological Sciences, Skidmore College, First Responder Health and Safety Laboratory, Saratoga Springs, NY, USA.ORCID 0000-0002-5838-8103
Skidmore College · USUniversidade de Brasília · BRHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow endogenous testosterone has been associated with increased cardiovascular risk in men.

objectivesTo determine the prevalence of low serum testosterone level (TT) in a cohort of male US career firefighters and to examine its relation with left ventricular wall thickness (LVWT). MATERIALS AND

methodsWe conducted a cross-sectional study among 341 career firefighters, (age: 37.5 ± 10.3 years; BMI: 28.9 ± 4.5 kg/m

resultsThe prevalence of low TT was 10.6% and of borderline was 26.4%, while 58.7% had levels in the reference range. The low-TT group was older and had higher BMI and SBP as compared to the reference group (P < .01). LVWT values were different among groups (P = .04) and significantly lower in firefighters with borderline-low TT as compared to the reference group (P < .05). This finding also occurred within obese firefighters (P = .03). The borderline-low group had a higher adjusted risk for a low LVWT as compared to the reference group [OR: 4.11 (95% CI: 1.79-9.43)]. DISCUSSION: Our findings highlight the possible relationship between a mild reduction in testosterone levels (borderline) and lower LVWT.

conclusionsA high prevalence of subnormal TT levels (low and borderline: 37%) was observed in this relatively homogeneous cohort of career firefighters. Mildly decreased TT levels and lower LVWT might represent a preclinical condition and a window of opportunity for cardiovascular preventive interventions in firefighters.

Indexed as

AdultCross-Sectional StudiesFirefightersFloridaHeart VentriclesHumansHypogonadismMaleRetrospective StudiesTestosteroneVentricular FunctionTestosteronecardiac structurecardiovascular riskfirefighterheartleft ventricularpreclinical testosterone deficiencytestosterone

Identifiers

PMID32633472
PMCPMC7693063
OpenAlexW3041851113

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.