Evidence map›Paper›PMID 32633070›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Distinct roles for major and minor antigen barriers in chimerism-based tolerance under irradiation-free conditions.

Benedikt Mahr, Nina Pilat, Nicolas Granofszky, Moritz Muckenhuber, Lukas W Unger, Anna M Weijler, Mario Wiletel, Romy Steiner, Lisa Dorner, Heinz Regele and 1 more

Abstract read
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In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Distinct roles for major and minor antigen barriers in chimerism-based tolerance under irradiation-free conditions.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Benedikt MahrSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5255-381X
Nina PilatSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4071-9397
Nicolas GranofszkySection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Moritz MuckenhuberSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Lukas W UngerSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-8423-2268
Anna M WeijlerSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Mario WiletelSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Romy SteinerSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Lisa DornerSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Heinz RegeleClinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Thomas WekerleSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5159-2796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eliminating cytoreductive conditioning from chimerism-based tolerance protocols would facilitate clinical translation. Here we investigated the impact of major histocompatibility complex (MHC) and minor histocompatibility antigen (MiHA) barriers on mechanisms of tolerance and rejection in this setting. Transient depletion of natural killer (NK) cells at the time of bone marrow (BM) transplantation (BMT) (20 × 10

Indexed as

ChimerismImmune ToleranceAnimalsBone Marrow TransplantationMiceMice, Inbred BALB CMice, Inbred C57BLSkin TransplantationTransplantation ChimeraTransplantation Tolerancebasic (laboratory) research/scienceimmunobiologytolerance: chimerismtolerance: costimulation blockadetolerance: experimentaltolerance: mechanisms

Identifiers

PMID32633070
PMCPMC7984377

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.