ArticleThe Journal of comparative neurology2021
Light sheet microscopy of the gerbil cochlea.
Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Implications of phase difference and amplitude ratio from intracochlear and extracochlear electrocochleography in normal-hearing guinea pigs.Frontiers in neuroscience · 2026Article
- Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing.Communications biology · 2025Article
- Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae.iScience · 2025Article
- Article
- Neural Degeneration in Normal-Aging Human Cochleas: Machine-Learning Counts and 3D Mapping in Archival Sections.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Three-dimensional mouse cochlea imaging based on the modified Sca/eS using confocal microscopy.Anatomical science international · 2023Article
- Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging.iScience · 2022Article
- Neural Contributions to the Cochlear Summating Potential: Spiking and Dendritic Components.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Evaluation of the Efficacy of Dexamethasone-Eluting Electrode Array on the Post-Implant Cochlear Fibrotic Reaction by Three-Dimensional Immunofluorescence Analysis in Mongolian Gerbil Cochlea.Journal of clinical medicine · 2021Article
- Multiscale photonic imaging of the native and implanted cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- In Situ 3D-Imaging of the Inner Ear Synapses with a Cochlear Implant.Life (Basel, Switzerland) · 2021Article
- Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy.Biomedical optics express · 2020Article
- Longitudinal Analysis of Intracochlear Electrocochleographic Amplitude Patterns in Cochlear Implant Recipients.Ear and hearingArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Light sheet fluorescence microscopy (LSFM) provides a rapid and complete three-dimensional image of the cochlea. The method retains anatomical relationships-on a micrometer scale-between internal structures such as hair cells, basilar membrane (BM), and modiolus with external surface structures such as the round and oval windows. Immunolabeled hair cells were used to visualize the spiraling BM in the intact cochlea without time intensive dissections or additional histological processing; yet material prepared for LSFM could be rehydrated, the BM dissected out and reimaged at higher resolution with the confocal microscope. In immersion-fixed material, details of the cochlear vasculature were seen throughout the cochlea. Hair cell counts (both inner and outer) as well as frequency maps of the BM were comparable to those obtained by other methods, but with the added dimension of depth. The material provided measures of angular, linear, and vector distance between characteristic frequency regions along the BM. Thus, LSFM provides a unique ability to rapidly image the entire cochlea in a manner applicable to model and interpret physiological results. Furthermore, the three-dimensional organization of the cochlea can be studied at the organ and cellular level with LSFM, and this same material can be taken to the confocal microscope for detailed analysis at the subcellular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.