Evidence map›Paper›PMID 32632896›Full record

ArticleJournal of neuro-oncology2020

Pontine gliomas a 10-year population-based study: a report from The Canadian Paediatric Brain Tumour Consortium (CPBTC).

Adriana Fonseca, Samina Afzal, Lynette Bowes, Bruce Crooks, Valerie Larouche, Nada Jabado, Sebastien Perreault, Donna L Johnston, Shayna Zelcer, Adam Fleming and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle.Diagnostics (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 16 institutions in 3 countries.

Adriana FonsecaDivision of Haematology Oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada. adriana.fonseca@sickkids.ca.ORCID http://orcid.org/0000-0002-6382-6833
Samina AfzalIWK Health Center, Dalhousie University, Halifax, B3K 6R8, Canada.
Lynette BowesJaneway Child Health Center, Memorial University, St. John's, A1B 3V6, Canada.
Bruce CrooksIWK Health Center, Dalhousie University, Halifax, B3K 6R8, Canada.
Valerie LaroucheCHU de Québec- Université Laval, Laval University, Québec, G1V 4G2, Canada.
Nada JabadoMontreal Children's Hospital, McGill University, Montreal, H4A 3J1, Canada.
Sebastien PerreaultCentre Hospitalier Universitaire Sainte, Justine, Université de Montreal, Montreal, H3T 1C5, Canada.
Donna L JohnstonChildren's Hospital of Eastern Ontario, University of Ottawa, Ottawa, K1H 8L1, Canada.
Shayna ZelcerLondon Health Sciences Children's Hospital, Western University, London, N6A 5A5, Canada.
Adam FlemingMcMaster Children's Hospital, McMaster University, Hamilton, L8P 1H1, Canada.
Katrin ScheinemannMcMaster Children's Hospital, McMaster University, Hamilton, L8P 1H1, Canada.
Mariana SilvaKingston General Hospital, Queens University, Kingston, K7L 2V7, Canada.
Magimairajan Issai VananCancer Care Manitoba, Pediatrics and Child Health, University of Manitoba, Winnipeg, R3E 0V9, Canada.
Chris MpofuJim Pattison Children's Hospital, University of Saskatchewan, Saskatoon, S7N 0W8, Canada.
Beverly WilsonStollery Children's Hospital, University of Alberta, Edmonton, T6G 2B7, Canada.
David D EisenstatStollery Children's Hospital, University of Alberta, Edmonton, T6G 2B7, Canada.
Lucie Lafay-CousinAlberta Children's Hospital, University of Calgary, Calgary, T3B 6A8, Canada.
Juliette HukinBC Children's Hospital, University of British Columbia, Vancouver, V6H 3N1, Canada.
Cynthia HawkinsDivision of Haematology Oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.
Ute BartelsDivision of Haematology Oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.
Eric BouffetDivision of Haematology Oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.
University of Toronto · CADalhousie University · CAUniversity of Alberta · CACancerCare Manitoba · CACentre Hospitalier Universitaire Sainte-Justine · CAMcMaster Children's Hospital · CAMemorial University of Newfoundland · CAMontreal Children's Hospital · CAQueen's University · CAUniversité Laval · CAUniversity of Basel · CHUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Ottawa · CAUniversity of Saskatchewan · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiffuse intrinsic pontine gliomas (DIPG) are midline gliomas that arise from the pons and the majority are lethal within a few months after diagnosis. Due to the lack of histological diagnosis the epidemiology of DIPG is not completely understood. The aim of this report is to provide population-based data to characterize the descriptive epidemiology of this condition in Canadian children. PATIENTS AND

methodsA national retrospective study of children and adolescents diagnosed with DIPG between 2000 and 2010 was undertaken. All cases underwent central review to determine clinical and radiological diagnostic characteristics. Crude incidence figures were calculated using age-adjusted (0-17 year) population data from Statistics Canada. Survival analyses were performed using the Kaplan-Meier method.

resultsA total of 163 patients with pontine lesions were identified. Central review determined one-hundred and forty-three patients who met clinical, radiological and/or histological criteria for diagnosis. We estimate an incidence rate of 1.9 DIPG/1,000,000 children/year in the Canadian population over a 10 years period. Median age at diagnosis was 6.8 years and 50.3% of patients were female. Most patients presented with cranial nerve palsies (76%) and ataxia (66%). Despite typical clinical and radiological characteristics, histological confirmation reported three lesions to be low-grade gliomas and three were diagnosed as CNS embryonal tumor not otherwise specified (NOS).

conclusionsOur study highlights the challenges associated with epidemiology studies on DIPG and the importance of central review for incidence rate estimations. It emphasizes that tissue biopsies are required for accurate histological and molecular diagnosis in patients presenting with pontine lesions and reinforces the limitations of radiological and clinical diagnosis in DIPG. Likewise, it underscores the urgent need to increase the availability and accessibility to clinical trials.

Indexed as

AdolescentBrain Stem NeoplasmsCanadaChemoradiotherapyChildChild, PreschoolDiffuse Intrinsic Pontine GliomaFemaleFollow-Up StudiesHumansInfantInfant, NewbornMalePrognosisRetrospective StudiesSurvival RateBrainstem tumorsDiffuse intrinsic pontine glioma (DIPG)EpidemiologyH3K27M

Identifiers

PMID32632896
OpenAlexW3041294355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.