ReviewCurrent obesity reports2020
Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity?
Review in Current obesity reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- High BMI and the risk for incident type 1 Diabetes Mellitus: a systematic review and meta-analysis of aggregated cohort studies.Cardiovascular diabetology · 2023Pooled it
- Association between circulating resistin levels and thyroid dysfunction: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.European journal of nutrition · 2021Trial
- Obesity in Adults with Type 1 Diabetes Mellitus.Journal of obesity & metabolic syndrome · 2026Review
- Obesity and risk of immune-mediated inflammatory diseases: a real-world propensity score-matched cohort study using electronic health records.Scientific reports · 2026Article
- Differences in Thyroid Autoimmunity and Thyroid Function Tests Between Individuals with and without Obesity: Is There a Correlation with Obesity Degree?Endocrine, metabolic & immune disorders drug targets · 2026Article
- Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations.Journal of translational medicine · 2025Article
- The Contribution of BMI to a Young Child's Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2.Diabetes care · 2025Article
- Correlation between body mass index and disease activity in patients with systemic lupus erythematosus from China.Advances in rheumatology (London, England) · 2025Article
- Increased Risk of Type 1 Diabetes in Boys Under the Age of 5 Years During COVID-19 Lockdowns in Finland, Sweden and Stanford, CA, USA-An Observational Multicenter Study.Diabetes/metabolism research and reviews · 2025Observational
- Impact of body mass index on clinical presentation and prognosis in myasthenia gravis.Orphanet journal of rare diseases · 2025Observational
- A Scoping Review on the Prevalence of Hashimoto's Thyroiditis and the Possible Associated Factors.Medical sciences (Basel, Switzerland) · 2025Article
- Article
- Association between body roundness index and osteoarthritis/rheumatoid arthritis: a cross-sectional study.Scientific reports · 2025Article
- Anti-Inflammatory Effects of SGLT2 Inhibitors: Focus on Macrophages.International journal of molecular sciences · 2025Review
- Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus.Frontiers in medicine · 2025Article
- Prevalence of Metabolic Syndrome and Autoimmune Markers in Adults: A Cross-Sectional Study From Türkiye.International journal of endocrinology · 2025Article
- Autoantibody production in pregnancy: relationship with mRNA BNT162b2 immunization, active COVID-19, and pre-eclampsia.Frontiers in immunology · 2025Article
- High-fat diet-induced adipose tissue-resident macrophages, T cells, and dendritic cells modulate chronic inflammation and adipogenesis during obesity.Frontiers in immunology · 2025Article
- Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto's thyroiditis: insights from efferocytosis regulation.Frontiers in medicine · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewDuring the last decades, obesity and autoimmune disorders have shown a parallel significant rise in industrialized countries. This review aims at providing a comprehensive update of the relationship between the adipose tissue in obesity and autoimmune disorders, highlighting the underlying mechanisms with a particular emphasis on adipokines and pro-inflammatory cytokines, the impaired B cell activity, and the production of natural and pathogenic autoantibody repertoire in the context of obesity. RECENT
findingsObesity is related to a higher risk of rheumatoid arthritis, psoriasis and psoriatic arthritis, multiple sclerosis, and Hashimoto's thyroiditis, while it may promote inflammatory bowel disorders and type 1 diabetes mellitus. Interestingly, subjects with obesity present more severe forms of these autoimmune disorders as well as decreased therapeutic response. Both obesity and autoimmune disorders present elevated levels of leptin, resistin, and visfatin. Autoantibody production, a hallmark of autoimmune disorders, has been demonstrated in obese animal models and human subjects. Obesity results in deficiencies of the human self-tolerance mechanisms by promoting pro-inflammatory processes, reducing Bregs as well as Tregs, and the latter resulting in increased Th17 and Th1 cells, creating the perfect milieu for the development of autoimmune disorders. More mechanistic, animal, and clinical studies are required to delineate the exact mechanisms underlying auto-reactivity in obesity as well as the adipose-immune crosstalk for potential successful therapeutic strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.