ArticleInternational journal of legal medicine2020
Intra- and intermuscular variations of postmortem protein degradation for PMI estimation.
Article in International journal of legal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Forensic applications of postmortem protein analysis in estimating the time since death: a systematic review.International journal of legal medicine · 2026Pooled it
- microRNAs as New Biomolecular Markers to Estimate Time since Death: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Post-mortem supravital skeletal muscle excitability for early post-mortem interval estimation: a scoping review and methodological map.Forensic science, medicine, and pathology · 2026Review
- Temporal RT-qPCR-Based Porcine Cardiac Molecular Profiling for Post-Mortem Interval Estimation: Predictive Modeling.International journal of molecular sciences · 2026Article
- Postmortem interval estimation through skeletal muscle protein degradation: a comprehensive review.International journal of legal medicine · 2026Review
- A Comparative Proteomics Study of Autopsy and Fresh-Frozen Coronary Artery Samples.Journal of proteome research · 2025Article
- Visual analysis of postmortem interval estimation trends and collaborative networks: a 15-year study (2006-2020).Forensic science, medicine, and pathology · 2025Article
- The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review.International journal of molecular sciences · 2024Review
- Forensic Proteomics for the Discovery of NewInternational journal of molecular sciences · 2023Article
- A standard protocol for the analysis of postmortem muscle protein degradation: process optimization and considerations for the application in forensic PMI estimation.International journal of legal medicine · 2022Article
- Systematic Review on Post-Mortem Protein Alterations: Analysis of Experimental Models and Evaluation of Potential Biomarkers of Time of Death.Diagnostics (Basel, Switzerland) · 2022Review
- Postmortem Protein Degradation as a Tool to Estimate the PMI: A Systematic Review.Diagnostics (Basel, Switzerland) · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
In recent years, protein decomposition has become of increasing interest for the use in forensic estimation of the postmortem interval (PMI). Especially skeletal muscle tissue has proven to be a prime target tissue, among other reasons, due to its large abundance in the human body. In this regard, it is important to know whether there are any intra- and intermuscular differences in the behavior of protein degradation. Thus, samples from different locations within several skeletal muscles as well as from cardiac and smooth muscle tissue samples were collected from three autopsy cases with varying degree of decomposition. Samples were analyzed by SDS-PAGE and Western blotting and compared for protein degradation patterns. Intramuscular variations turned out to be minimal and without major influence for the use of the method. Observed intermuscular differences provide possibilities for future improvement of the precision and temporal application range. The results of this study show the strengths and current limitations of protein degradation-based PMI estimation and provide a deeper understanding of intraindividual postmortem protein degradation processes.
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